Literature DB >> 1239275

On the defect of synthesis ceruloplasmin in the liver polyribosomes in Wilson's disease.

V S Gaitskhoki, O I Kisselev, K A Moshkov, L V Puchkova, M M Shavlovski, V S Shulman, V G Vacharlovski, S A Neifakh.   

Abstract

Comparative immunochemical analysis of ceruloplasmin-synthesizing polyribosomes in liver biopsies from control subjects and homozygous carriers of the Wilson's mutation was performed. According to I125-antibody binding data, the amount of ceruloplasmin-forming liver polysomes in patients with Wilson's disease was 10--20 times lower than that in non-Wilson patients. Correspondingly, the pulse labeling of ceruloplasmin polypeptides was decreased several-fold in the cell-free liver preparations from patients with Wilson's disease.

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Year:  1975        PMID： 1239275     DOI： 10.1007/bf00484913

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  16 in total

1.  Purification of ovalbumin messenger ribonucleic acid by specific immunoadsorption of ovalbumin-synthesizing polysomes and millipore partition of ribonucleic acid.

Authors:  R Palacios; D Sullivan; N M Summers; M L Kiely; R T Schimke
Journal:  J Biol Chem       Date:  1973-01-25       Impact factor: 5.157

2.  Wilson's disease in the United Kingdom and Taiwan. I. General characteristics of 142 cases and prognosis. II. A genetic analysis of 88 cases.

Authors:  G T Strickland; D Frommer; M L Leu; R Pollard; S Sherlock; J N Cumings
Journal:  Q J Med       Date:  1973-07

3.  Molecular pathology of ceruloplasmin.

Authors:  S A Neifakh; I M Vasiletz; M M Shavlovsky
Journal:  Biochem Genet       Date:  1972-04       Impact factor: 1.890

4.  Electrophoretic variation in human serum ceruloplasmin: a new genetic polymorphism.

Authors:  D C Shreffler; G J Brewer; J C Gall; M S Honeyman
Journal:  Biochem Genet       Date:  1967-09       Impact factor: 1.890

5.  The molecular structure of human ceruloplasmin: a proposed model.

Authors:  M H Shokeir
Journal:  Clin Biochem       Date:  1973-03       Impact factor: 3.281

6.  Isolation of messenger-like RNA from immunochemically separated polyribosomes.

Authors:  T L Delovitch; B K Davis; G Holme; A H Sehon
Journal:  J Mol Biol       Date:  1972-08-28       Impact factor: 5.469

7.  A genetic study of Wilson's disease: evidence for heterogeneity.

Authors:  D W Cox; F C Fraser; A Sass-Kortsak
Journal:  Am J Hum Genet       Date:  1972-11       Impact factor: 11.025

8.  Identification of ceruloplasmin in human liver cells by fluorescent antibodies and absence of this protein in Wilson disease.

Authors:  A M Shaposhnikov; Y N Zubzitski; V S Shulman
Journal:  Experientia       Date:  1969-04-15

9.  Two new ceruloplasmin variants in Negroes--data on three populations.

Authors:  M H Shokeir; D C Shreffler
Journal:  Biochem Genet       Date:  1970-08       Impact factor: 1.890

10.  Decreased globin messenger RNA in thalassemia detected by molecular hybridization.

Authors:  D L Kacian; R Gambino; L W Dow; E Grossbard; C Natta; F Ramirez; S Spiegelman; P A Marks; A Bank
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205
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  3 in total

1.  Isolation and partial purification of ceruloplasmin messenger RNA from rat liver.

Authors:  S A Neifakh; V S Gaitskhoki; N A Klimov; L V Puchkova; M M Shavlovski; A L Schwartzman
Journal:  Mol Biol Rep       Date:  1977-03       Impact factor: 2.316

2.  Preproceruloplasmin is a primary product of cell-free translation of ceruloplasmin messenger RNA.

Authors:  L V Puchkova; V S Gaitskhoki; N K Monakhov; L T Timchenko; S A Neifakh
Journal:  Mol Cell Biochem       Date:  1981-03-27       Impact factor: 3.396

3.  Highly purified ceruloplasmin messenger RNA from rat liver. Physico-chemical and functional characteristics.

Authors:  V S Gaitskhoki; V M L'vov; L V Puchkova; A L Schwartzman; S A Neifakh
Journal:  Mol Cell Biochem       Date:  1981-03-27       Impact factor: 3.396
  3 in total

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