Literature DB >> 12384391

Expression of SHV-2 beta-lactamase and of reduced amounts of OmpK36 porin in Klebsiella pneumoniae results in increased resistance to cephalosporins and carbapenems.

Brendan Crowley1, Vicente J Benedí, Antonio Doménech-Sánchez.   

Abstract

A Klebsiella pneumoniae clinical isolate was resistant to cefoxitin, cefotaxime, ceftazidime, ceftazidime-clavulanate, piperacillin-tazobactam (MICs, >256 micro g/ml in all cases), and meropenem (MIC, 16 micro g/ml) and was intermediate to imipenem (MIC, 8 micro g/ml). Decreased expression of the OmpK36 porin and expression of an SHV-2 beta-lactamase contributed to the observed resistance to these beta-lactam-containing agents.

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Year:  2002        PMID： 12384391      PMCID： PMC128712          DOI： 10.1128/AAC.46.11.3679-3682.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae.

Authors:  R Dutzler; G Rummel; S Albertí; S Hernández-Allés; P Phale; J Rosenbusch; V Benedí; T Schirmer
Journal:  Structure       Date:  1999-04-15       Impact factor: 5.006

2.  High-level resistance to cefotaxime and ceftazidime in Klebsiella pneumoniae isolates from Cleveland, Ohio.

Authors:  K S Thomson; C C Sanders; J A Washington
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

3.  Detection of genes coding for extended-spectrum SHV beta-lactamases in clinical isolates by a molecular genetic method, and comparison with the E test.

Authors:  M T Nüesch-Inderbinen; H Hächler; F H Kayser
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1996-05       Impact factor: 3.267

4.  Emergence of a carbapenem-resistant Klebsiella pneumoniae.

Authors:  F M MacKenzie; K J Forbes; T Dorai-John; S G Amyes; I M Gould
Journal:  Lancet       Date:  1997-09-13       Impact factor: 79.321

5.  Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae.

Authors:  L Martínez-Martínez; A Pascual; S Hernández-Allés; D Alvarez-Díaz; A I Suárez; J Tran; V J Benedí; G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

6.  Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein.

Authors:  P A Bradford; C Urban; N Mariano; S J Projan; J J Rahal; K Bush
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

7.  Carboxy-terminal phenylalanine is essential for the correct assembly of a bacterial outer membrane protein.

Authors:  M Struyvé; M Moons; J Tommassen
Journal:  J Mol Biol       Date:  1991-03-05       Impact factor: 5.469

8.  In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum-cephalosporins.

Authors:  L Martínez-Martínez; S Hernández-Allés; S Albertí; J M Tomás; V J Benedi; G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

9.  Outer membrane profiles of clonally related Klebsiella pneumoniae isolates from clinical samples and activities of cephalosporins and carbapenems.

Authors:  C Ardanuy; J Liñares; M A Domínguez; S Hernández-Allés; V J Benedí; L Martínez-Martínez
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

10.  A porin from Klebsiella pneumoniae: sequence homology, three-dimensional model, and complement binding.

Authors:  S Albertí; F Rodríquez-Quiñones; T Schirmer; G Rummel; J M Tomás; J P Rosenbusch; V J Benedí
Journal:  Infect Immun       Date:  1995-03       Impact factor: 3.441
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  26 in total

1.  Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence.

Authors:  Yu-Kuo Tsai; Chang-Phone Fung; Jung-Chung Lin; Jiun-Han Chen; Feng-Yee Chang; Te-Li Chen; L Kristopher Siu
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

2.  Predictability of Phenotype in Relation to Common β-Lactam Resistance Mechanisms in Escherichia coli and Klebsiella pneumoniae.

Authors:  Alex Agyekum; Alicia Fajardo-Lubián; Xiaoman Ai; Andrew N Ginn; Zhiyong Zong; Xuejun Guo; John Turnidge; Sally R Partridge; Jonathan R Iredell
Journal:  J Clin Microbiol       Date:  2016-02-24       Impact factor: 5.948

3.  Outbreaks in distinct regions due to a single Klebsiella pneumoniae clone carrying a bla VIM-1 metallo-{beta}-lactamase gene.

Authors:  Alexandros Ikonomidis; Despina Tokatlidou; Ioulia Kristo; Danai Sofianou; Athanassios Tsakris; Paraskevi Mantzana; Spyros Pournaras; Antonios N Maniatis
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

4.  Activity of Simulated Human Dosage Regimens of Meropenem and Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in an In Vitro Hollow-Fiber Model.

Authors:  Mojgan Sabet; Ziad Tarazi; Debora Rubio-Aparicio; Thomas G Nolan; Jonathan Parkinson; Olga Lomovskaya; Michael N Dudley; David C Griffith
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

5.  Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development.

Authors:  Ana Mena; Virginia Plasencia; Laura García; Olga Hidalgo; José Ignacio Ayestarán; Sebastián Alberti; Nuria Borrell; José L Pérez; Antonio Oliver
Journal:  J Clin Microbiol       Date:  2006-08       Impact factor: 5.948

6.  Detection of the Klebsiella pneumoniae carbapenemase (KPC) in K. pneumoniae Isolated from the Clinical Samples by the Phenotypic and Genotypic Methods.

Authors:  Masoume Bina; Abazar Pournajaf; Shiva Mirkalantari; Malihe Talebi; Gholamreza Irajian
Journal:  Iran J Pathol       Date:  2015

7.  Outbreak caused by an ertapenem-resistant, CTX-M-15-producing Klebsiella pneumoniae sequence type 101 clone carrying an OmpK36 porin variant.

Authors:  Aggeliki Poulou; Evangelia Voulgari; Georgia Vrioni; Vasiliki Koumaki; Grigorios Xidopoulos; Vasiliki Chatzipantazi; Fani Markou; Athanassios Tsakris
Journal:  J Clin Microbiol       Date:  2013-07-12       Impact factor: 5.948

8.  Evaluation of boronic acid disk tests for differentiating KPC-possessing Klebsiella pneumoniae isolates in the clinical laboratory.

Authors:  Athanassios Tsakris; Ioulia Kristo; Aggeliki Poulou; Katerina Themeli-Digalaki; Alexandros Ikonomidis; Dimitra Petropoulou; Spyros Pournaras; Danai Sofianou
Journal:  J Clin Microbiol       Date:  2008-12-10       Impact factor: 5.948

9.  Combined porin loss and extended spectrum beta-lactamase production is associated with an increasing imipenem minimal inhibitory concentration in clinical Klebsiella pneumoniae strains.

Authors:  Duo Yang; Yu Guo; Zheng Zhang
Journal:  Curr Microbiol       Date:  2009-02-14       Impact factor: 2.188

10.  Emergence of imipenem-resistant gram-negative bacilli in intestinal flora of intensive care patients.

Authors:  Laurence Armand-Lefèvre; Cécile Angebault; François Barbier; Emilie Hamelet; Gilles Defrance; Etienne Ruppé; Régis Bronchard; Raphaël Lepeule; Jean-Christophe Lucet; Assiya El Mniai; Michel Wolff; Philippe Montravers; Patrick Plésiat; Antoine Andremont
Journal:  Antimicrob Agents Chemother       Date:  2013-01-14       Impact factor: 5.191
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