Literature DB >> 12384386

Mutations in ribosomal protein L16 and in 23S rRNA in Enterococcus strains for which evernimicin MICs differ.

Myriam Zarazaga1, Carmen Tenorio, Rosa Del Campo, Fernanda Ruiz-Larrea, Carmen Torres.   

Abstract

Mutations in ribosomal protein L16 and in 23S rRNA were investigated in 22 Enterococcus strains of different species and for which the MICs of evernimicin differ (MICs, 0.023 to 16 micro g/ml). Amino acid changes (Arg56His, Ile52Thr, or Arg51His) in protein L16 were found in seven strains, and a nucleotide G2535A mutation in 23S rRNA was found in 1 strain among 13 for which the MICs are > or =1 micro g/ml.

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Year:  2002        PMID： 12384386      PMCID： PMC128729          DOI： 10.1128/AAC.46.11.3657-3659.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

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Authors:  L A Sechi; F M Zuccon; J E Mortensen; L Daneo-Moore
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Authors:  P M McNicholas; D J Najarian; P A Mann; D Hesk; R S Hare; K J Shaw; T A Black
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

4.  Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action.

Authors:  P V Adrian; W Zhao; T A Black; K J Shaw; R S Hare; K P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

5.  A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.

Authors:  L Belova; T Tenson; L Xiong; P M McNicholas; A S Mankin
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

6.  Antimicrobial Activity of SCH 27899, Oligosaccharide Member of the Everninomycin Class with a Wide Gram-Positive Spectrum.

Authors:  Ronald N. Jones; Mary S. Barrett
Journal:  Clin Microbiol Infect       Date:  1995-09       Impact factor: 8.067

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Authors:  F M Aarestrup; L B Jensen
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

8.  Effects of mutations in ribosomal protein L16 on susceptibility and accumulation of evernimicin.

Authors:  P M McNicholas; P A Mann; D J Najarian; L Miesel; R S Hare; T A Black
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

9.  EmtA, a rRNA methyltransferase conferring high-level evernimicin resistance.

Authors:  P A Mann; L Xiong; A S Mankin; A S Chau; C A Mendrick; D J Najarian; C A Cramer; D Loebenberg; E Coates; N J Murgolo; F M Aarestrup; R V Goering; T A Black; R S Hare; P M McNicholas
Journal:  Mol Microbiol       Date:  2001-09       Impact factor: 3.501

10.  Evernimicin (SCH27899) inhibits a novel ribosome target site: analysis of 23S ribosomal DNA mutants.

Authors:  P V Adrian; C Mendrick; D Loebenberg; P McNicholas; K J Shaw; K P Klugman; R S Hare; T A Black
Journal:  Antimicrob Agents Chemother       Date:  2000-11       Impact factor: 5.191
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5.  Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.

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Review 6.  Bioactive oligosaccharide natural products.

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