Literature DB >> 12383770

Hepatitis C: molecular virology and antiviral targets.

Darius Moradpour1, Volker Brass, Rainer Gosert, Benno Wölk, Hubert E Blum.   

Abstract

Chronic hepatitis C is a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. Although current treatment options are limited, progress in understanding the molecular virology of hepatitis C has led to the identification of novel antiviral targets. Moreover, in vitro and in vivo model systems have been developed that allow systematic evaluation of new therapeutic strategies. This review details current concepts in molecular virology and emerging therapies for hepatitis C.

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Year:  2002        PMID： 12383770     DOI： 10.1016/s1471-4914(02)02395-x

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  14 in total

1.  Development of cell-based assays for in vitro characterization of hepatitis C virus NS3/4A protease inhibitors.

Authors:  Victoria Chung; Anthony R Carroll; Norman M Gray; Nigel R Parry; Pia A Thommes; K Claire Viner; Eric A D'Souza
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

2.  Improvement of quantitative testing of liver function in patients with chronic hepatitis C after installment of antiviral therapy.

Authors:  Matthias Ocker; Marion Ganslmayer; Steffen Zopf; Susanne Gahr; Christopher Janson; Eckhart-G Hahn; Christoph Herold
Journal:  World J Gastroenterol       Date:  2005-09-21       Impact factor: 5.742

3.  Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus.

Authors:  Byounghoon Hwang; Jung Sun Cho; Hyeon Ju Yeo; Jung-Hye Kim; Kyung Min Chung; Kyungsook Han; Sung Key Jang; Seong-Wook Lee
Journal:  RNA       Date:  2004-07-09       Impact factor: 4.942

4.  Investigating a new generation of ribozymes in order to target HCV.

Authors:  Michel V Lévesque; Dominique Lévesque; Francis P Brière; Jean-Pierre Perreault
Journal:  PLoS One       Date:  2010-03-10       Impact factor: 3.240

5.  A Conserved Inhibitory Mechanism of a Lycorine Derivative against Enterovirus and Hepatitis C Virus.

Authors:  Yu Guo; Yaxin Wang; Lin Cao; Peng Wang; Jie Qing; Qizhen Zheng; Luqing Shang; Zheng Yin; Yuna Sun
Journal:  Antimicrob Agents Chemother       Date:  2015-11-23       Impact factor: 5.191

6.  Genetic interactions between hepatitis C virus replicons.

Authors:  Matthew J Evans; Charles M Rice; Stephen P Goff
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

7.  HCV genetics and genotypes dictate future antiviral strategies.

Authors:  Louis Papageorgiou; Chrisanthy Vlachakis; Konstantina Dragoumani; Sofia Raftopoulou; Dimitrios Brouzas; Nicolas C Nicolaides; George P Chrousos; Evangelia Charmandari; Vasileios Megalooikonomou; Dimitrios Vlachakis
Journal:  J Mol Biochem       Date:  2017-12-10

Review 8.  Hepatitis C virus, mitochondria and auto/mitophagy: exploiting a host defense mechanism.

Authors:  Vitalba Ruggieri; Carmela Mazzoccoli; Valerio Pazienza; Angelo Andriulli; Nazzareno Capitanio; Claudia Piccoli
Journal:  World J Gastroenterol       Date:  2014-03-14       Impact factor: 5.742

9.  Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes.

Authors:  Darius Moradpour; Matthew J Evans; Rainer Gosert; Zhenghong Yuan; Hubert E Blum; Stephen P Goff; Brett D Lindenbach; Charles M Rice
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

10.  Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons.

Authors:  Rainer Gosert; Denise Egger; Volker Lohmann; Ralf Bartenschlager; Hubert E Blum; Kurt Bienz; Darius Moradpour
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103
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