Literature DB >> 1238122

Step conductance increases in bilayer membranes induced by antibody-antigen-complement action.

D Wobschall, C McKeon.   

Abstract

A sharp rise in the electrical conductance of lipid bilayer membranes was observed following the addition of antigen (bovine serum), antibody (rabbit anti-bovine serum), and complement to the neighboring aqueous phases. At low concentrations, step increases in the conductivity occurred which are consistent with the appearance of about 2.2 nm holes in the membrane. Probably attack or lysis of the lipid bilayer by complement is responsible.

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Year:  1975        PMID： 1238122     DOI： 10.1016/0005-2736(75)90117-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  11 in total

1.  Pore formation by complement in the outer membrane of gram-negative bacteria studied with asymmetric planar lipopolysaccharide/phospholipid bilayers.

Authors:  G Schröder; K Brandenburg; L Brade; U Seydel
Journal:  J Membr Biol       Date:  1990-11       Impact factor: 1.843

2.  Increased ion permeability of planar lipid bilayer membranes after treatment with the C5b-9 cytolytic attack mechanism of complement.

Authors:  D W Michaels; A S Abramovitz; C H Hammer; M M Mayer
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

3.  Single-channel analysis of the conductance fluctuations induced in lipid bilayer membranes by complement proteins C5b-9.

Authors:  R Benz; A Schmid; T Wiedmer; P J Sims
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

4.  Bilayer lipid membranes (BLM) study of antigen-antibody interactions.

Authors:  J D Mountz; H T Tien
Journal:  J Bioenerg Biomembr       Date:  1978-12       Impact factor: 2.945

5.  Membrane attack complex of complement: generation of high-affinity phospholipid binding sites by fusion of five hydrophilic plasma proteins.

Authors:  E R Podack; G Biesecker; H J Müller-Eberhard
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

6.  Steady-state analysis of tracer exchange across the C5b-9 complement lesion in a biological membrane.

Authors:  P J Sims; P K Lauf
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

7.  Single channel currents induced by complement in antibody-coated cell membranes.

Authors:  M B Jackson; C L Stephens; H Lecar
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

Review 8.  The membrane attack complex.

Authors:  H J Müller-Eberhard
Journal:  Springer Semin Immunopathol       Date:  1984

Review 9.  Is the membrane attack complex of complement an enzyme?

Authors:  M D Boyle
Journal:  Mol Cell Biochem       Date:  1984       Impact factor: 3.396

10.  The use of antibody and complement to gain access to the interior of presynaptic nerve terminals.

Authors:  E S Schweitzer; M P Blaustein
Journal:  Exp Brain Res       Date:  1980       Impact factor: 1.972
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