Literature DB >> 12378391

Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination.

I R Cohen1.   

Abstract

The autoimmune process that produces Type I (insulin-dependent) diabetes mellitus seems to respond favourably to therapeutic vaccination with a peptide of the 60 kDa heat shock protein. This article is a personal review of the observations and the thinking that gave rise to the idea of therapeutic peptide vaccination. The rationale for vaccination therapy is compared to other approaches aimed at specific immunological treatment for autoimmune disease.

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Year:  2002        PMID： 12378391     DOI： 10.1007/s00125-002-0937-z

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  8 in total

1.  Chimeric vaccine composed of viral peptide and mammalian heat-shock protein 60 peptide protects against West Nile virus challenge.

Authors:  Orly Gershoni-Yahalom; Shimon Landes; Smadar Kleiman-Shoval; David Ben-Nathan; Michal Kam; Bat-El Lachmi; Yevgeny Khinich; Michael Simanov; Itzhak Samina; Anat Eitan; Irun R Cohen; Bracha Rager-Zisman; Angel Porgador
Journal:  Immunology       Date:  2010-03-16       Impact factor: 7.397

2.  Protective effect of human heat shock protein 60 suggested by its association with decreased seropositivity to pathogens.

Authors:  A Steptoe; A Shamaei-Tousi; A Gylfe; L Bailey; S Bergström; A R Coates; B Henderson
Journal:  Clin Vaccine Immunol       Date:  2007-01-03

3.  Neonatal oral administration of DiaPep277, combined with hydrolysed casein diet, protects against Type 1 diabetes in BB-DP rats. An experimental study.

Authors:  S Brugman; F A Klatter; J Visser; N A Bos; D Elias; J Rozing
Journal:  Diabetologia       Date:  2004-07-10       Impact factor: 10.122

4.  Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes.

Authors:  V A L Huurman; P E van der Meide; G Duinkerken; S Willemen; I R Cohen; D Elias; B O Roep
Journal:  Clin Exp Immunol       Date:  2008-04-16       Impact factor: 4.330

5.  Diversity of physiological cell reactivity to heat shock protein 60 in different mouse strains.

Authors:  Ernesto Luna; Edilberto Postol; Cristina Caldas; Luiz R Mundel; Georgia Porto; Leo K Iwai; Paulo Lee Ho; Jorge Kalil; Verônica Coelho
Journal:  Cell Stress Chaperones       Date:  2007       Impact factor: 3.667

6.  Pemphigus vulgaris is characterized by low IgG reactivities to specific self-antigens along with high IgG reactivity to desmoglein 3.

Authors:  Ittai Fattal; Jacob Rimer; Noam Shental; Yair Molad; Armando Gabrielli; Avi Livneh; Ofer Sarig; Ilan Goldberg; Uzi Gafter; Eytan Domany; Irun R Cohen
Journal:  Immunology       Date:  2014-11       Impact factor: 7.397

Review 7.  Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease.

Authors:  E Zonneveld-Huijssoon; S Albani; B J Prakken; F van Wijk
Journal:  Clin Exp Immunol       Date:  2013-01       Impact factor: 4.330

Review 8.  Peptides as Therapeutic Agents for Dengue Virus.

Authors:  Miaw-Fang Chew; Keat-Seong Poh; Chit-Laa Poh
Journal:  Int J Med Sci       Date:  2017-10-15       Impact factor: 3.738
  8 in total

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