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Literature DB >> 12376619

Protection of the intestinal mucosa by intraepithelial gamma delta T cells.

Yaping Chen¹, Kevin Chou, Elaine Fuchs, Wendy L Havran, Richard Boismenu.

Abstract

gammadelta intraepithelial T lymphocytes (IEL) represent a major T cell population within the intestine of unclear functional relevance. The role of intestinal gammadelta IEL was evaluated in the dextran sodium sulfate (DSS) induced mouse colitis model system. Large numbers of gammadelta T cells, but not alphabeta T cells, were localized at sites of DSS-induced epithelial cell damage. gammadelta IEL in DSS treated mice expressed keratinocyte growth factor (KGF), a potent intestinal epithelial cell mitogen. gammadelta cell-deficient mice (TCRdelta(-/-)) and KGF-deficient mice (KGF(-/-)), but not alphabeta cell-deficient mice (TCRalpha(-/-)), were more prone than wild-type mice to DSS-induced mucosal injury and demonstrated delayed tissue repair after termination of DSS treatment. Termination of DSS treatment resulted in vigorous epithelial cell proliferation in wild-type mice but not in TCRdelta(-/-) mice or KGF(-/-) mice. These results suggest that gammadelta IEL help preserve the integrity of damaged epithelial surfaces by providing the localized delivery of an epithelial cell growth factor.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2002 PMID： 12376619 PMCID： PMC137885 DOI： 10.1073/pnas.212290499

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

47 in total

1. Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.

Authors: H Komano; Y Fujiura; M Kawaguchi; S Matsumoto; Y Hashimoto; S Obana; P Mombaerts; S Tonegawa; H Yamamoto; S Itohara
Journal: Proc Natl Acad Sci U S A Date: 1995-06-20 Impact factor: 11.205

2. Modulation of epithelial cell growth by intraepithelial gamma delta T cells.

Authors: R Boismenu; W L Havran
Journal: Science Date: 1994-11-18 Impact factor: 47.728

3. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

Authors: R M Housley; C F Morris; W Boyle; B Ring; R Biltz; J E Tarpley; S L Aukerman; P L Devine; R H Whitehead; G F Pierce
Journal: J Clin Invest Date: 1994-11 Impact factor: 14.808

4. Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor.

Authors: T R Ulich; E S Yi; R Cardiff; S Yin; N Bikhazi; R Biltz; C F Morris; G F Pierce
Journal: Am J Pathol Date: 1994-05 Impact factor: 4.307

5. Clinicopathologic study of dextran sulfate sodium experimental murine colitis.

Authors: H S Cooper; S N Murthy; R S Shah; D J Sedergran
Journal: Lab Invest Date: 1993-08 Impact factor: 5.662

6. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.

Authors: S Werner; H Smola; X Liao; M T Longaker; T Krieg; P H Hofschneider; L T Williams
Journal: Science Date: 1994-11-04 Impact factor: 47.728

7. Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease.

Authors: R Giacomelli; I Parzanese; G Frieri; A Passacantando; F Pizzuto; T Pimpo; P Cipriani; A Viscido; R Caprilli; G Tonietti
Journal: Clin Exp Immunol Date: 1994-10 Impact factor: 4.330

8. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.

Authors: S Itohara; P Mombaerts; J Lafaille; J Iacomini; A Nelson; A R Clarke; M L Hooper; A Farr; S Tonegawa
Journal: Cell Date: 1993-02-12 Impact factor: 41.582

Protection of the intestinal mucosa by intraepithelial gamma delta T cells.

1. Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.

2. Modulation of epithelial cell growth by intraepithelial gamma delta T cells.

3. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

4. Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor.

5. Clinicopathologic study of dextran sulfate sodium experimental murine colitis.

6. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds.

7. Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease.

8. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.

9. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice.

10. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo.

Review 1. Intraepithelial lymphocytes in celiac disease immunopathology.

Review 2. Immunomodulation at epithelial sites by obesity and metabolic disease.

Review 3. The role of gamma/delta T cells in immunity to infection and regulation of inflammation.

Review 4. Selection of self-reactive T cells in the thymus.

Review 5. Immunoregulation by the gut microbiota.

Review 6. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity.

7. T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.

8. Choroidal γδ T cells in protection against retinal pigment epithelium and retinal injury.

Review 9. The microbiome and regulation of mucosal immunity.

Review 10. Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes.