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Literature DB >> 12372621

WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.

Tetsuro Morisaki¹, Toru Hirota, Shin-ichi Iida, Tomotoshi Marumoto, Toshihiro Hara, Yasuyuki Nishiyama, Michio Kawasuzi, Takehisa Hiraoka, Tatsuyuki Mimori, Norie Araki, Ichiro Izawa, Masaki Inagaki, Hideyuki Saya.

Abstract

Identification of physiological substrates for Cdc2/cyclin B is crucial for understanding the functional link between mitotic events and Cdc2/cyclin B activation. A human homologue of the Drosophila warts tumor suppressor, termed WARTS, is a serine/threonine kinase and a dynamic component of the mitotic apparatus. We have found that Cdc2/cyclin B forms a complex with a fraction of WARTS in the centrosome and phosphorylates the Ser613 site of WARTS during mitosis. Immunocytochemical analysis has shown that the S613-phosphorylated WARTS appears in the spindle poles at prometaphase and disappears at telophase. Our findings suggest that Cdc/cyclin B regulates functions of WARTS on the mitotic apparatus.

Entities: Chemical Disease Gene Species

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Year: 2002 PMID： 12372621 DOI： 10.1016/s0014-5793(02)03360-4

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

18 in total

1. Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice.

Authors: Weixing Shen; Faiyaz Ahmad; Steven Hockman; John Ma; Hitoshi Omi; Nalini Raghavachari; Vincent Manganiello
Journal: Cell Cycle Date: 2010-12-01 Impact factor: 4.534

2. KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1.

Authors: Ling Xiao; Yuanhong Chen; Ming Ji; Deanna J Volle; Robert E Lewis; Ming-Ying Tsai; Jixin Dong
Journal: J Biol Chem Date: 2011-08-30 Impact factor: 5.157

Review 3. The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.

Authors: Noa Furth; Yael Aylon
Journal: Cell Death Differ Date: 2017-06-23 Impact factor: 15.828

4. Warts phosphorylates mud to promote pins-mediated mitotic spindle orientation in Drosophila, independent of Yorkie.

Authors: Evan B Dewey; Desiree Sanchez; Christopher A Johnston
Journal: Curr Biol Date: 2015-10-22 Impact factor: 10.834

5. CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation.

Authors: Shuping Yang; Lin Zhang; Miao Liu; Rong Chong; Shi-Jian Ding; Yuanhong Chen; Jixin Dong
Journal: Cancer Res Date: 2013-10-07 Impact factor: 12.701

WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.

1. Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice.

2. KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1.

Review 3. The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.

4. Warts phosphorylates mud to promote pins-mediated mitotic spindle orientation in Drosophila, independent of Yorkie.

5. CDK1 phosphorylation of YAP promotes mitotic defects and cell motility and is essential for neoplastic transformation.

6. The mob as tumor suppressor gene is essential for early development and regulates tissue growth in Drosophila.

7. KIBRA: In the brain and beyond.

Review 8. The interplay between centrosomes and the Hippo tumor suppressor pathway.

9. Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

10. Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice.