| Literature DB >> 12372606 |
Isabelle Gourdier1, Maguy Del Rio, Laure Crabbé, Laurent Candeil, Virginie Copois, Marc Ychou, Charles Auffray, Pierre Martineau, Nadir Mechti, Yves Pommier, Bernard Pau.
Abstract
To investigate acquired resistance to oxaliplatin, we selected two resistant clones from the HCT116 cell line. We found that the resistant phenotype was associated with resistance to oxaliplatin-induced apoptosis as demonstrated by FACS analysis and by Western blotting of caspase 3 activation. In addition, the resistant phenotype showed a concomitant resistance to lonidamine and arsenic trioxide which are inducers of mitochondrial apoptosis. Furthermore, a complete loss of Bax expression due to a frameshift mutation was observed in the most resistant clone. Taken together, these findings suggest that altered mitochondrial-mediated apoptosis could play a role in oxaliplatin resistance.Entities:
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Year: 2002 PMID： 12372606 DOI： 10.1016/s0014-5793(02)03347-1
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124