Literature DB >> 12372518

DNA Interaction and photonicking properties of DNA-targeted acridine (2,2'-Bipyridine)platinum(II) complexes.

Lourdes Gude1, María-José Fernández, Kathryn B Grant, Antonio Lorente.   

Abstract

Synthesis of two (2,2'-bipyridine)platinum(II) complexes tethered to one or two acridine chromophores is reported. These acridine complexes efficiently unwind and photocleave supercoiled plasmid DNA under physiological conditions of temperature and pH.

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Year:  2002        PMID： 12372518     DOI： 10.1016/s0960-894x(02)00657-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3.

Authors:  Wen Zhou; Mohammad Almeqdadi; Michael E Xifaras; Imogen A Riddell; Ömer H Yilmaz; Stephen J Lippard
Journal:  Chem Commun (Camb)       Date:  2018-03-13       Impact factor: 6.222

2.  Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4'-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2'-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers.

Authors:  Tzu-Chun Kan; Mei-Hsiang Lin; Chun-Chia Cheng; Jeng-Wei Lu; Ming-Thau Sheu; Yuan-Soon Ho; Sri Rahayu; Jungshan Chang
Journal:  Pharmaceutics       Date:  2022-04-11       Impact factor: 6.525
  2 in total

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