| Literature DB >> 12372516 |
T G Murali Dhar1, Chunjian Liu, William J Pitts, Junquing Guo, Scott H Watterson, Henry Gu, Catherine A Fleener, Katherine Rouleau, N Z Sherbina, Joel C Barrish, Diane Hollenbaugh, Edwin J Iwanowicz.
Abstract
A series of heterocyclic replacements for the central diamide moiety of 1, a potent small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH) were explored The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for these new series of inhibitors is given.Entities:
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Year: 2002 PMID： 12372516 DOI： 10.1016/s0960-894x(02)00641-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823