Literature DB >> 1237150

The action of ionizing radiation on DNA in the presence of quinacrine. I. UV absorption and fluorescence measurements.

A Hissung, H Dertinger, G Heinrich.   

Abstract

It is shown by UV absorption and absolute fluorescence spectroscopy of solutions containing both DNA and quinacrine that the components experience mutual radio-protection due to scavenging of water radicals. From measurements at different ionic strengths it is inferred that quinacrine bound to DNA is more efficiently protected than the free compound. Furthermore, release of bound quinacrine from DNA is observed at higher doses.

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Year:  1975        PMID： 1237150     DOI： 10.1007/bf02339804

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN： 0301-634X            Impact factor:   1.925


  14 in total

1.  The structure of the DNA-acridine complex.

Authors:  L S LERMAN
Journal:  Proc Natl Acad Sci U S A       Date:  1963-01-15       Impact factor: 11.205

2.  The action of ionizing radiation on DNA in the presence of quinacrine. II. DNA strand breakage.

Authors:  A Hissung; H Dertinger
Journal:  Radiat Environ Biophys       Date:  1975-06-13       Impact factor: 1.925

3.  Rejoining of single breaks of DNA induced by x-rays in mammalian cells: effects of metabolic inhibitors.

Authors:  A Tsuboi; T Terasima
Journal:  Mol Gen Genet       Date:  1970

4.  Effect of quinacrine on survival and DNA repair in x-irradiated Chinese hamster cells.

Authors:  N Voiculetz; K C Smith; H S Kaplan
Journal:  Cancer Res       Date:  1974-05       Impact factor: 12.701

5.  The influence of post-irradiation conditions on the survival of Chinese hamster cells after gamma-irradiation.

Authors:  C F Arlett
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1970

6.  The interaction of aminocridines with nucleic acids.

Authors:  A Blake; A R Peacocke
Journal:  Biopolymers       Date:  1968       Impact factor: 2.505

7.  Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.

Authors:  R L O'Brien; J G Olenick; F E Hahn
Journal:  Proc Natl Acad Sci U S A       Date:  1966-06       Impact factor: 11.205

8.  Effect of quinacrine on x-ray sensitivity and the repair of damaged DNA in Escherichia coli K-12.

Authors:  Z Fuks; K C Smith
Journal:  Radiat Res       Date:  1971-10       Impact factor: 2.841

9.  Sub-lethal and lethal radiation damage.

Authors:  M M Elkind; H Sutton-Gilbert; W B Moses; C Kamper
Journal:  Nature       Date:  1967-06-10       Impact factor: 49.962

10.  Quinacrine, a chromosome stain specific for deoxyadenylate-deoxythymidylaterich regions in DNA.

Authors:  B Weisblum; P L De Haseth
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205
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  2 in total

1.  The action of ionizing radiation on DNA in the presence of quinacrine. II. DNA strand breakage.

Authors:  A Hissung; H Dertinger
Journal:  Radiat Environ Biophys       Date:  1975-06-13       Impact factor: 1.925

2.  The action of ionizing radiation on DNA in the presence of quinacrine. III. E.S.R. study: spin transfer in gamma-irradiated lyophilized DNA-quinacrine complexes.

Authors:  A Hissung; K F Weibezahn
Journal:  Radiat Environ Biophys       Date:  1976-07-30       Impact factor: 1.925
  2 in total

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