UNLABELLED: This study was performed to evaluate a possible artifact related to the administration of intravascular contrast agent in dual-modality PET/CT imaging. METHODS: Thirty oncology patients underwent whole-body PET/CT. CT images, which were collected in the presence of intravenous and oral iodinated contrast agent, were used for PET attenuation correction. PET images were assessed for the artifact, defined as a region of high count rate on attenuation-corrected images in accurate coregistration with a contrast-enhanced blood vessel. Intravascular enhancement of thoracic veins was quantified by application of regions of interest, and quantities in patients with the artifact (group 1) and without the artifact (group 2) were correlated. Body surface area was calculated for all patients. RESULTS: The contrast-induced PET artifact was present in 4 (13%) of 30 patients. Mean density differences in intravascular enhancement were highly significant (P < 0.001) in a comparison of group 1 (2,262 +/- 304 Hounsfield units [HU]) and group 2 (1,058 +/- 209 HU). Body surface area was significantly lower (P = 0.035) in the patients of group 1 (1.67 +/- 0.11 m(2)) than in the patients of group 2 (2.01 +/- 0.18 m(2)). CONCLUSION: Contrast-enhanced dual-modality PET/CT examinations may result in a PET artifact that is due to the transient bolus passage of undiluted intravenous contrast agent.
UNLABELLED: This study was performed to evaluate a possible artifact related to the administration of intravascular contrast agent in dual-modality PET/CT imaging. METHODS: Thirty oncology patients underwent whole-body PET/CT. CT images, which were collected in the presence of intravenous and oral iodinated contrast agent, were used for PET attenuation correction. PET images were assessed for the artifact, defined as a region of high count rate on attenuation-corrected images in accurate coregistration with a contrast-enhanced blood vessel. Intravascular enhancement of thoracic veins was quantified by application of regions of interest, and quantities in patients with the artifact (group 1) and without the artifact (group 2) were correlated. Body surface area was calculated for all patients. RESULTS: The contrast-induced PET artifact was present in 4 (13%) of 30 patients. Mean density differences in intravascular enhancement were highly significant (P < 0.001) in a comparison of group 1 (2,262 +/- 304 Hounsfield units [HU]) and group 2 (1,058 +/- 209 HU). Body surface area was significantly lower (P = 0.035) in the patients of group 1 (1.67 +/- 0.11 m(2)) than in the patients of group 2 (2.01 +/- 0.18 m(2)). CONCLUSION: Contrast-enhanced dual-modality PET/CT examinations may result in a PET artifact that is due to the transient bolus passage of undiluted intravenous contrast agent.
Authors: Florian F Behrendt; Yavuz Temur; Frederik A Verburg; Moritz Palmowski; Thomas Krohn; Hubertus Pietsch; Christiane K Kuhl; Felix M Mottaghy Journal: Eur Radiol Date: 2012-06-04 Impact factor: 5.315
Authors: Philip Aschoff; Christian Plathow; Thomas Beyer; Matthias P Lichy; Gunter Erb; Mehmet Ö Öksüz; Claus D Claussen; Christina Pfannenberg Journal: Eur J Nucl Med Mol Imaging Date: 2011-11-29 Impact factor: 9.236
Authors: Ashley M Groves; Irfan Kayani; John C Dickson; Caroline Townsend; Ian Croasdale; Rizwan Syed; Nagesh Nagabushan; Sharon F Hain; Peter J Ell; Jamshed B Bomanji Journal: Eur J Nucl Med Mol Imaging Date: 2005-06-04 Impact factor: 9.236
Authors: Tira Bunyaviroch; Timothy G Turkington; Terence Z Wong; John W Wilson; James G Colsher; R Edward Coleman Journal: Mol Imaging Biol Date: 2007-12-21 Impact factor: 3.488