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Literature DB >> 12368362

The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.

Stephan Ludwig¹, Xiuyan Wang, Christina Ehrhardt, Hongyong Zheng, Nicola Donelan, Oliver Planz, Stephan Pleschka, Adolfo García-Sastre, Gudrun Heins, Thorsten Wolff.

Abstract

The influenza A virus nonstructural NS1 protein is known to modulate host cell gene expression and to inhibit double-stranded RNA (dsRNA)-mediated antiviral responses. Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.

Entities: Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12368362 PMCID： PMC136597 DOI： 10.1128/jvi.76.21.11166-11171.2002

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

45 in total

Review 1. AP-1: one switch for many signals.

Authors: R Wisdom
Journal: Exp Cell Res Date: 1999-11-25 Impact factor: 3.905

2. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.

Authors: J Talon; C M Horvath; R Polley; C F Basler; T Muster; P Palese; A García-Sastre
Journal: J Virol Date: 2000-09 Impact factor: 5.103

Review 3. Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures.

Authors: S Goodbourn; L Didcock; R E Randall
Journal: J Gen Virol Date: 2000-10 Impact factor: 3.891

4. Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus.

Authors: T Aragón; S de la Luna; I Novoa; L Carrasco; J Ortín; A Nieto
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

Review 5. Organization and regulation of mitogen-activated protein kinase signaling pathways.

Authors: T P Garrington; G L Johnson
Journal: Curr Opin Cell Biol Date: 1999-04 Impact factor: 8.382

6. p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells.

Authors: K Kujime; S Hashimoto; Y Gon; K Shimizu; T Horie
Journal: J Immunol Date: 2000-03-15 Impact factor: 5.422

7. JNK2 and IKKbeta are required for activating the innate response to viral infection.

Authors: W M Chu; D Ostertag; Z W Li; L Chang; Y Chen; Y Hu; B Williams; J Perrault; M Karin
Journal: Immunity Date: 1999-12 Impact factor: 31.745

8. Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.

Authors: M Bergmann; A Garcia-Sastre; E Carnero; H Pehamberger; K Wolff; P Palese; T Muster
Journal: J Virol Date: 2000-07 Impact factor: 5.103

9. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin.

Authors: K C Goh; M J deVeer; B R Williams
Journal: EMBO J Date: 2000-08-15 Impact factor: 11.598

Review 10. Viral double-stranded RNA, cytokines, and the flu.

Authors: J A Majde
Journal: J Interferon Cytokine Res Date: 2000-03 Impact factor: 2.607

83 in total

1. A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice.

Authors: Nicola R Donelan; Christopher F Basler; Adolfo García-Sastre
Journal: J Virol Date: 2003-12 Impact factor: 5.103

2. Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles.

Authors: Urtzi Garaigorta; Ana M Falcón; Juan Ortín
Journal: J Virol Date: 2005-12 Impact factor: 5.103

3. Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus.

Authors: Masaki Mibayashi; Luis Martínez-Sobrido; Yueh-Ming Loo; Washington B Cárdenas; Michael Gale; Adolfo García-Sastre
Journal: J Virol Date: 2006-11-01 Impact factor: 5.103

4. Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.

Authors: Christina Ehrhardt; Thorsten Wolff; Stephan Pleschka; Oliver Planz; Wiebke Beermann; Johannes G Bode; Mirco Schmolke; Stephan Ludwig
Journal: J Virol Date: 2007-01-17 Impact factor: 5.103

5. The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway.

Authors: Ji-Young Min; Robert M Krug
Journal: Proc Natl Acad Sci U S A Date: 2006-04-20 Impact factor: 11.205

6. Novel influenza virus NS1 antagonists block replication and restore innate immune function.

Authors: Dipanwita Basu; Marcin P Walkiewicz; Matthew Frieman; Ralph S Baric; David T Auble; Daniel A Engel
Journal: J Virol Date: 2008-12-03 Impact factor: 5.103

7. The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV.

Authors: Wenjun Ma; Dominique Brenner; Zhongfang Wang; Bianca Dauber; Christina Ehrhardt; Katrin Högner; Susanne Herold; Stephan Ludwig; Thorsten Wolff; Kangzhen Yu; Jürgen A Richt; Oliver Planz; Stephan Pleschka
Journal: J Virol Date: 2009-12-09 Impact factor: 5.103