Literature DB >> 10846107

Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.

M Bergmann1, A Garcia-Sastre, E Carnero, H Pehamberger, K Wolff, P Palese, T Muster.   

Abstract

The availability of an influenza virus NS1 gene knockout virus (delNS1 virus) allowed us to establish the significance of the biological relationship between the influenza virus NS1 protein and double-stranded-RNA-activated protein kinase (PKR) in the life cycle and pathogenicity of influenza virus. Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.

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Year:  2000        PMID： 10846107      PMCID： PMC112122          DOI： 10.1128/jvi.74.13.6203-6206.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

1.  Regulation of IFN-alpha/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells.

Authors:  T Ronni; S Matikainen; T Sareneva; K Melén; J Pirhonen; P Keskinen; I Julkunen
Journal:  J Immunol       Date:  1997-03-01       Impact factor: 5.422

2.  Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK.

Authors:  M Gale; C M Blakely; D A Hopkins; M W Melville; M Wambach; P R Romano; M G Katze
Journal:  Mol Cell Biol       Date:  1998-02       Impact factor: 4.272

Review 3.  The double-stranded RNA-dependent protein kinase PKR: structure and function.

Authors:  M J Clemens; A Elia
Journal:  J Interferon Cytokine Res       Date:  1997-09       Impact factor: 2.607

4.  The N-terminal half of the influenza virus NS1 protein is sufficient for nuclear retention of mRNA and enhancement of viral mRNA translation.

Authors:  R M Marión; T Aragón; A Beloso; A Nieto; J Ortín
Journal:  Nucleic Acids Res       Date:  1997-11-01       Impact factor: 16.971

5.  The molecular chaperone hsp40 regulates the activity of P58IPK, the cellular inhibitor of PKR.

Authors:  M W Melville; W J Hansen; B C Freeman; W J Welch; M G Katze
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-07       Impact factor: 11.205

6.  Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis.

Authors:  B Jansen; H Schlagbauer-Wadl; H G Eichler; K Wolff; A van Elsas; P I Schrier; H Pehamberger
Journal:  Cancer Res       Date:  1997-02-01       Impact factor: 12.701

7.  Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways.

Authors:  A Zhou; J M Paranjape; S D Der; B R Williams; R H Silverman
Journal:  Virology       Date:  1999-06-05       Impact factor: 3.616

8.  Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB.

Authors:  A Kumar; Y L Yang; V Flati; S Der; S Kadereit; A Deb; J Haque; L Reis; C Weissmann; B R Williams
Journal:  EMBO J       Date:  1997-01-15       Impact factor: 11.598

9.  Cleavage of oligoribonucleotides by the 2',5'-oligoadenylate- dependent ribonuclease L.

Authors:  S S Carroll; E Chen; T Viscount; J Geib; M K Sardana; J Gehman; L C Kuo
Journal:  J Biol Chem       Date:  1996-03-01       Impact factor: 5.157

10.  Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

Authors:  Y L Yang; L F Reis; J Pavlovic; A Aguzzi; R Schäfer; A Kumar; B R Williams; M Aguet; C Weissmann
Journal:  EMBO J       Date:  1995-12-15       Impact factor: 11.598
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  155 in total

1.  Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.

Authors:  J Talon; C M Horvath; R Polley; C F Basler; T Muster; P Palese; A García-Sastre
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

2.  Protein synthesis shut-off induced by influenza virus infection is independent of PKR activity.

Authors:  T Zürcher; R M Marión; J Ortín
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

3.  Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.

Authors:  Sabine Steidle; Luis Martínez-Sobrido; Markus Mordstein; Stefan Lienenklaus; Adolfo García-Sastre; Peter Stäheli; Georg Kochs
Journal:  J Virol       Date:  2010-10-06       Impact factor: 5.103

4.  Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon.

Authors:  X Wang; M Li; H Zheng; T Muster; P Palese; A A Beg; A García-Sastre
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

5.  A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice.

Authors:  Nicola R Donelan; Christopher F Basler; Adolfo García-Sastre
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

6.  The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors.

Authors:  Stephan Ludwig; Xiuyan Wang; Christina Ehrhardt; Hongyong Zheng; Nicola Donelan; Oliver Planz; Stephan Pleschka; Adolfo García-Sastre; Gudrun Heins; Thorsten Wolff
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

7.  Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis.

Authors:  John C Kash; Dawn M Cunningham; Maria W Smit; Youngwoo Park; David Fritz; Jeffrey Wilusz; Michael G Katze
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

8.  NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response.

Authors:  Zhongfang Wang; Nicole C Robb; Eva Lenz; Thorsten Wolff; Ervin Fodor; Stephan Pleschka
Journal:  J Virol       Date:  2010-08-25       Impact factor: 5.103

9.  The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV.

Authors:  Wenjun Ma; Dominique Brenner; Zhongfang Wang; Bianca Dauber; Christina Ehrhardt; Katrin Högner; Susanne Herold; Stephan Ludwig; Thorsten Wolff; Kangzhen Yu; Jürgen A Richt; Oliver Planz; Stephan Pleschka
Journal:  J Virol       Date:  2009-12-09       Impact factor: 5.103

10.  Contribution of double-stranded RNA and CPSF30 binding domains of influenza virus NS1 to the inhibition of type I interferon production and activation of human dendritic cells.

Authors:  Irene Ramos; Elena Carnero; Dabeiba Bernal-Rubio; Christopher W Seibert; Liset Westera; Adolfo García-Sastre; Ana Fernandez-Sesma
Journal:  J Virol       Date:  2012-12-19       Impact factor: 5.103
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