| Literature DB >> 12368359 |
I Wayne Cheney1, Vicky C H Lai, Weidong Zhong, Tessa Brodhag, Shannon Dempsey, Charmaine Lim, Zhi Hong, Johnson Y N Lau, Robert C Tam.
Abstract
A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-gamma and IFN-alpha/beta with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression.Entities:
Mesh:
Substances:
Year: 2002 PMID: 12368359 PMCID: PMC136623 DOI: 10.1128/jvi.76.21.11148-11154.2002
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103