AIM: The majority of patients with hepatic malignancies are not suitable for potentially curative resection due to tumour size, location, inadequate hepatic reserve or widely spread disease. Radiofrequency ablation (RFA) is a novel technique of local tumour destruction by heat. The aim of this study was to report the initial experience with RFA in the management of primary and metastatic liver tumours in New Zealand. METHODS: Patients who underwent RFA between February 2000 and August 2001 were included. The clinical, pathological and follow-up information of individual patients entered prospectively on a computerised database was collated and analysed. RESULTS: Thirty one procedures were performed in 30 patients (18 male, median age 58 years). Nineteen procedures were performed percutaneously under ultrasound guidance and twelve were carried out as part of a surgical procedure. Eight patients had primary tumours, and 22 patients had metastatic tumours (colorectal 9, neuroendocrine 7, non-colorectal non-neuroendocrine 6). The median diameter of treated lesions was 25 mm (range 5 60 mm). The median number of treated lesions per patient was 2 (range 1 6). Twenty four of the 31 procedures were classified as curative (all disease treated). Six patients with neuroendocrine tumours underwent cytoreduction only and were classified as palliative. Eight patients (4 percutaneous, 4 surgical) developed complications leading to 3 prolonged hospital stays (bile leak, abscess and burn). There was no treatment-related mortality. At a median follow up of 12 months (range 1 22 months), 6 patients (all treated with percutaneous RFA) have developed tumour recurrence in treated lesions, 5 patients have developed new liver lesions, 16 are alive and disease free, and 3 have developed extra hepatic disease. CONCLUSIONS: RFA is safe but significant complications can occur. RFA and enteral resection should not be undertaken together, as there is an increased risk of hepatic sepsis and abscess. RFA performed percutaneously is associated with a higher rate of recurrence than RFA performed at operation.
AIM: The majority of patients with hepatic malignancies are not suitable for potentially curative resection due to tumour size, location, inadequate hepatic reserve or widely spread disease. Radiofrequency ablation (RFA) is a novel technique of local tumour destruction by heat. The aim of this study was to report the initial experience with RFA in the management of primary and metastatic liver tumours in New Zealand. METHODS:Patients who underwent RFA between February 2000 and August 2001 were included. The clinical, pathological and follow-up information of individual patients entered prospectively on a computerised database was collated and analysed. RESULTS: Thirty one procedures were performed in 30 patients (18 male, median age 58 years). Nineteen procedures were performed percutaneously under ultrasound guidance and twelve were carried out as part of a surgical procedure. Eight patients had primary tumours, and 22 patients had metastatic tumours (colorectal 9, neuroendocrine 7, non-colorectal non-neuroendocrine 6). The median diameter of treated lesions was 25 mm (range 5 60 mm). The median number of treated lesions per patient was 2 (range 1 6). Twenty four of the 31 procedures were classified as curative (all disease treated). Six patients with neuroendocrine tumours underwent cytoreduction only and were classified as palliative. Eight patients (4 percutaneous, 4 surgical) developed complications leading to 3 prolonged hospital stays (bile leak, abscess and burn). There was no treatment-related mortality. At a median follow up of 12 months (range 1 22 months), 6 patients (all treated with percutaneous RFA) have developed tumour recurrence in treated lesions, 5 patients have developed new liver lesions, 16 are alive and disease free, and 3 have developed extra hepatic disease. CONCLUSIONS: RFA is safe but significant complications can occur. RFA and enteral resection should not be undertaken together, as there is an increased risk of hepatic sepsis and abscess. RFA performed percutaneously is associated with a higher rate of recurrence than RFA performed at operation.
Authors: Laura Fugazzola; Rossella Elisei; Dagmar Fuhrer; Barbara Jarzab; Sophie Leboulleux; Kate Newbold; Jan Smit Journal: Eur Thyroid J Date: 2019-08-28
Authors: Steven A Curley; Paolo Marra; Karen Beaty; Lee M Ellis; J Nicolas Vauthey; Eddie K Abdalla; Courtney Scaife; Chan Raut; Robert Wolff; Haesun Choi; Evelyne Loyer; Paolo Vallone; Francesco Fiore; Fabrizio Scordino; Vincenzo De Rosa; Raffaele Orlando; Sandro Pignata; Bruno Daniele; Francesco Izzo Journal: Ann Surg Date: 2004-04 Impact factor: 12.969