Literature DB >> 12360192

Furin at the cutting edge: from protein traffic to embryogenesis and disease.

Gary Thomas1.   

Abstract

Furin catalyses a simple biochemical reaction--the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever. This review summarizes various features of furin--its structural and enzymatic properties, intracellular localization, trafficking, substrates, and roles in vivo.

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Year:  2002        PMID： 12360192      PMCID： PMC1964754          DOI： 10.1038/nrm934

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  169 in total

1.  A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells.

Authors:  H Fölsch; H Ohno; J S Bonifacino; I Mellman
Journal:  Cell       Date:  1999-10-15       Impact factor: 41.582

2.  Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.

Authors:  Saurav Misra; Rosa Puertollano; Yukio Kato; Juan S Bonifacino; James H Hurley
Journal:  Nature       Date:  2002-02-21       Impact factor: 49.962

3.  Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence.

Authors:  Graham Simmons; Rouven J Wool-Lewis; Frédéric Baribaud; Robert C Netter; Paul Bates
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

4.  The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.

Authors:  Eric D Anderson; Sean S Molloy; François Jean; Hao Fei; Satoko Shimamura; Gary Thomas
Journal:  J Biol Chem       Date:  2002-01-17       Impact factor: 5.157

5.  Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.

Authors:  Yiping Wu; Shoshana Yakar; Ling Zhao; Lothar Hennighausen; Derek LeRoith
Journal:  Cancer Res       Date:  2002-02-15       Impact factor: 12.701

6.  The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

Authors:  Lucia Pastorino; Annat F Ikin; Angus C Nairn; Amit Pursnani; Joseph D Buxbaum
Journal:  Mol Cell Neurosci       Date:  2002-02       Impact factor: 4.314

7.  Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins.

Authors:  James M Binley; Rogier W Sanders; Aditi Master; Charmagne S Cayanan; Cheryl L Wiley; Linnea Schiffner; Bruce Travis; Shawn Kuhmann; Dennis R Burton; Shiu-Lok Hu; William C Olson; John P Moore
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

8.  Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization.

Authors:  Nor Eddine Sounni; Eugenia N Baramova; Carine Munaut; Erik Maquoi; Francis Frankenne; Jean-Michel Foidart; Agnès Noël
Journal:  Int J Cancer       Date:  2002-03-01       Impact factor: 7.396

9.  Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4.

Authors:  Haleh Mahloogi; Daniel E Bassi; Andres J P Klein-Szanto
Journal:  Carcinogenesis       Date:  2002-04       Impact factor: 4.944

10.  Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.

Authors:  Farrah Kheradmand; Kirtee Rishi; Zena Werb
Journal:  J Cell Sci       Date:  2002-02-15       Impact factor: 5.285
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  464 in total

1.  E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.

Authors:  Tao Yang; Roberto Mendoza-Londono; Huifang Lu; Jianning Tao; Kaiyi Li; Bettina Keller; Ming Ming Jiang; Rina Shah; Yuqing Chen; Terry K Bertin; Feyza Engin; Branka Dabovic; Daniel B Rifkin; John Hicks; Milan Jamrich; Arthur L Beaudet; Brendan Lee
Journal:  J Clin Invest       Date:  2010-06-07       Impact factor: 14.808

2.  Role of PACS-1 in trafficking of human cytomegalovirus glycoprotein B and virus production.

Authors:  Colin M Crump; Chien-Hui Hung; Laurel Thomas; Lei Wan; Gary Thomas
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

3.  Subtleties among subtilases. The structural biology of Kex2 and furin-related prohormone convertases.

Authors:  Charles Brenner
Journal:  EMBO Rep       Date:  2003-10       Impact factor: 8.807

4.  Structures of immature flavivirus particles.

Authors:  Ying Zhang; Jeroen Corver; Paul R Chipman; Wei Zhang; Sergei V Pletnev; Dagmar Sedlak; Timothy S Baker; James H Strauss; Richard J Kuhn; Michael G Rossmann
Journal:  EMBO J       Date:  2003-06-02       Impact factor: 11.598

5.  Identification of furin pro-region determinants involved in folding and activation.

Authors:  Lyne Bissonnette; Gabriel Charest; Jean-Michel Longpré; Pierre Lavigne; Richard Leduc
Journal:  Biochem J       Date:  2004-05-01       Impact factor: 3.857

6.  The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.

Authors:  Gregory K Scott; Feng Gu; Colin M Crump; Laurel Thomas; Lei Wan; Yang Xiang; Gary Thomas
Journal:  EMBO J       Date:  2003-12-01       Impact factor: 11.598

7.  Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein.

Authors:  Ayako Ueo; Marie Kubota; Yuta Shirogane; Shinji Ohno; Takao Hashiguchi; Yusuke Yanagi
Journal:  J Virol       Date:  2020-06-01       Impact factor: 5.103

8.  PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

Authors:  Mesut Eren; Amanda E Boe; Sheila B Murphy; Aaron T Place; Varun Nagpal; Luisa Morales-Nebreda; Daniela Urich; Susan E Quaggin; G R Scott Budinger; Gökhan M Mutlu; Toshio Miyata; Douglas E Vaughan
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-28       Impact factor: 11.205

9.  Mutagenesis of D80-82 and G83 residues in West Nile Virus NS2B: effects on NS2B-NS3 activity and viral replication.

Authors:  Fan Jia; Jingjing Fan; Bo Zhang; Zhiming Yuan
Journal:  Virol Sin       Date:  2013-01-16       Impact factor: 4.327

10.  Opposite roles of furin and PC5A in N-cadherin processing.

Authors:  Deborah Maret; Mohamad Seyed Sadr; Emad Seyed Sadr; David R Colman; Rolando F Del Maestro; Nabil G Seidah
Journal:  Neoplasia       Date:  2012-10       Impact factor: 5.715
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