OBJECTIVE: To estimate potential costs and benefits of routinely using tandem mass spectrometry (MS/MS) to screen newborns for inborn errors of metabolism. METHOD: Analysis of costs and benefits resulting from use of MS/MS in screening of 32 000 newborn infants using data from the Kaiser Permanente Medical Care Program of Northern California plus other published data. SETTING: A large health maintenance organization. RESULTS: In the base scenario, the cost per quality-adjusted life year saved by MS/MS screening was $5827; in the least favorable scenario, this cost was $11 419, and in the most favorable scenario, $736. CONCLUSION: Costs per quality-adjusted life year saved by MS/MS screening for inborn errors of metabolism compare favorably with other mass screening programs, including those for breast and prostate cancer.
OBJECTIVE: To estimate potential costs and benefits of routinely using tandem mass spectrometry (MS/MS) to screen newborns for inborn errors of metabolism. METHOD: Analysis of costs and benefits resulting from use of MS/MS in screening of 32 000 newborn infants using data from the Kaiser Permanente Medical Care Program of Northern California plus other published data. SETTING: A large health maintenance organization. RESULTS: In the base scenario, the cost per quality-adjusted life year saved by MS/MS screening was $5827; in the least favorable scenario, this cost was $11 419, and in the most favorable scenario, $736. CONCLUSION: Costs per quality-adjusted life year saved by MS/MS screening for inborn errors of metabolism compare favorably with other mass screening programs, including those for breast and prostate cancer.
Authors: Kenneth D Long; Elizabeth V Woodburn; Huy M Le; Utsav K Shah; Steven S Lumetta; Brian T Cunningham Journal: Lab Chip Date: 2017-09-26 Impact factor: 6.799
Authors: Javier H Gonzalez; Girish S Shirali; Andrew M Atz; Sarah N Taylor; Geoffrey A Forbus; Sinai C Zyblewski; Anthony M Hlavacek Journal: Pediatr Cardiol Date: 2008-12-11 Impact factor: 1.655