Literature DB >> 12355375

A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population.

Kerrie Tosh1, Sarah Meisner, M Ruby Siddiqui, Karuppiah Balakrishnan, Satish Ghei, Marina Golding, Utpal Sengupta, Ramasamy M Pitchappan, Adrian V S Hill.   

Abstract

A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.

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Year:  2002        PMID： 12355375     DOI： 10.1086/343806

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

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Review 3.  Macrophage immunoregulatory pathways in tuberculosis.

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Review 6.  Leprosy as a genetic model for susceptibility to common infectious diseases.

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8.  Human polymorphisms as clinical predictors in leprosy.

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Review 9.  Evolution, revolution and heresy in the genetics of infectious disease susceptibility.

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10.  Chromosome 2p14 is linked to susceptibility to leprosy.

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