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Literature DB >> 12349958

Indomethacin protects against neurodegeneration caused by MPTP intoxication in mice.

I Kurkowska-Jastrzebska¹, M Babiuch, I Joniec, A Przybyłkowski, A Członkowski, A Członkowska.

Abstract

The anti-inflammatory agents are postulated to be effective in treating neurodegenerative disorders. In this study, we showed that indomethacin (IND) in the dose of 1 mg/kg protected neurons against toxic damage caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice model of Parkinson's disease. IND also diminished microglial activation and lymphocytic infiltration in the injured areas. These observations suggest that anti-inflammatory properties of IND may play a role in the neuron's protection in this model. However, diminished inflammatory reaction may be secondary to less neuronal damage.

Entities: Chemical Disease Species

Mesh：

Substances：
Indomethacin

Year: 2002 PMID： 12349958 DOI： 10.1016/s1567-5769(02)00078-4

Source DB: PubMed Journal: Int Immunopharmacol ISSN： 1567-5769 Impact factor: 4.932

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Cited

22 in total

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2. Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation.

Authors: Xianwu Li; Eiron Cudaback; C Dirk Keene; Richard M Breyer; Thomas J Montine
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9. Time-course evaluation of whole blood phagocytosis in mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

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Review 10. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Authors: Elizabeth A Mazzio; Fran Close; Karam F A Soliman
Journal: Int J Mol Sci Date: 2011-01-17 Impact factor: 5.923

Indomethacin protects against neurodegeneration caused by MPTP intoxication in mice.

1. Exosomes as drug delivery vehicles for Parkinson's disease therapy.

2. Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation.

Review 3. Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease.

4. Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity.

5. A macrophage-nanozyme delivery system for Parkinson's disease.

6. Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease.

7. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.

8. Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy.

9. Time-course evaluation of whole blood phagocytosis in mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Review 10. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.