Literature DB >> 12323062

Highly diastereoselective multicomponent synthesis of unsymmetrical imidazolines.

Satymaheshwar Peddibhotla1, S Jayakumar, Jetze J Tepe.   

Abstract

We report here a highly diastereoselective multicomponent synthesis of imidazolines. These low molecular weight scaffolds contain a four-point diversity applicable to alkyl, aryl, acyl, and hetereocyclic substitutions. [structure: see text]

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Year:  2002        PMID: 12323062     DOI: 10.1021/ol026703y

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  3 in total

1.  Gold(I)-catalyzed diastereo- and enantioselective 1,3-dipolar cycloaddition and Mannich reactions of azlactones.

Authors:  Asa D Melhado; Giovanni W Amarante; Z Jane Wang; Marco Luparia; F Dean Toste
Journal:  J Am Chem Soc       Date:  2011-02-22       Impact factor: 15.419

2.  Azomethine ylide mediated inversion of configuration of quaternary imidazoline carbon: converting trans- to its cis- imidazolines.

Authors:  Ke Qu; Jason S Fisk; Jetze J Tepe
Journal:  Tetrahedron Lett       Date:  2011-09-21       Impact factor: 2.415

3.  Inhibition of the human proteasome by imidazoline scaffolds.

Authors:  Lauren M Azevedo; Theresa A Lansdell; Jacob R Ludwig; Robert A Mosey; Daljinder K Woloch; Dillon P Cogan; Gregory P Patten; Michael R Kuszpit; Jason S Fisk; Jetze J Tepe
Journal:  J Med Chem       Date:  2013-07-03       Impact factor: 7.446

  3 in total

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