Literature DB >> 12322965

Poly(epsilon-caprolactone) as a potential material for a temporary joint spacer.

A P D Elfick1.   

Abstract

Sepsis of a total joint replacement may not respond to treatment with systemic antibiotics. In these circumstances the treatment is often a two-stage revision of the prosthesis; the infected prosthesis is removed, a period of treatment with an antibiotic-loaded joint spacer ensues, finally a new total joint is implanted once the infection has subsided. A PMMA temporary joint spacer offering a degree of functionality is gaining popularity. Patient activity will cause this temporary implant to wear, releasing potentially damaging PMMA particles into the joint environment. An alternative biodegradable polymer is proposed for use as a temporary joint spacer. This study details initial investigations into the wear behaviour of one such polymer, poly(epsilon-caprolactone). A multi-directional pin-on-plate wear tester was used to assess the performance of poly(epsilon-caprolactone) against a stainless-steel counterface. Two lubricating conditions were studied: distilled water and bovine serum. In water the wear rate of the poly(epsilon-caprolactone), 0.35 x 10(-6) mm3/N m, was comparable to that of polyethylene. However, in bovine serum the wear rate was greater, 18.09 x 10(-6) mm3/Nm. This result compares favourably with PTFE wear rates, suggesting that the wear of poly(epsilon-caprolactone) in this specialised application may be acceptable.

Entities:  

Mesh:

Substances:

Year:  2002        PMID: 12322965     DOI: 10.1016/s0142-9612(02)00163-1

Source DB:  PubMed          Journal:  Biomaterials        ISSN: 0142-9612            Impact factor:   12.479


  9 in total

1.  Biological characteristic effects of human dental pulp stem cells on poly-ε-caprolactone-biphasic calcium phosphate fabricated scaffolds using modified melt stretching and multilayer deposition.

Authors:  Natkrita Wongsupa; Thongchai Nuntanaranont; Suttatip Kamolmattayakul; Nuttawut Thuaksuban
Journal:  J Mater Sci Mater Med       Date:  2017-01-09       Impact factor: 3.896

2.  Cross-linking characteristics and mechanical properties of an injectable biomaterial composed of polypropylene fumarate and polycaprolactone co-polymer.

Authors:  Jun Yan; Jianmin Li; M Brett Runge; Mahrokh Dadsetan; Qingshan Chen; Lichun Lu; Michael J Yaszemski
Journal:  J Biomater Sci Polym Ed       Date:  2010-06-21       Impact factor: 3.517

3.  Assessment of bone regeneration of a tissue-engineered bone complex using human dental pulp stem cells/poly(ε-caprolactone)-biphasic calcium phosphate scaffold constructs in rabbit calvarial defects.

Authors:  Natkrita Wongsupa; Thongchai Nuntanaranont; Suttatip Kamolmattayakul; Nuttawut Thuaksuban
Journal:  J Mater Sci Mater Med       Date:  2017-04-06       Impact factor: 3.896

4.  Electrophoretic deposition of silicon-substituted hydroxyapatite/poly(epsilon-caprolactone) composite coatings.

Authors:  Xiufeng Xiao; Rongfang Liu; Xiaolian Tang
Journal:  J Mater Sci Mater Med       Date:  2008-10-24       Impact factor: 3.896

Review 5.  Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration.

Authors:  Angshuman Bharadwaz; Ambalangodage C Jayasuriya
Journal:  Mater Sci Eng C Mater Biol Appl       Date:  2020-01-29       Impact factor: 7.328

6.  MiR-221-inhibited adipose tissue-derived mesenchymal stem cells bioengineered in a nano-hydroxy apatite scaffold.

Authors:  Saghar Hoseinzadeh; Amir Atashi; Masoud Soleimani; Effat Alizadeh; Nosratollah Zarghami
Journal:  In Vitro Cell Dev Biol Anim       Date:  2016-01-28       Impact factor: 2.416

7.  Stem cells, growth factors and scaffolds in craniofacial regenerative medicine.

Authors:  Viktor Tollemar; Zach J Collier; Maryam K Mohammed; Michael J Lee; Guillermo A Ameer; Russell R Reid
Journal:  Genes Dis       Date:  2015-10-17

8.  A Three-Dimensional Printed Polycaprolactone-Biphasic-Calcium-Phosphate Scaffold Combined with Adipose-Derived Stem Cells Cultured in Xenogeneic Serum-Free Media for the Treatment of Bone Defects.

Authors:  Woraporn Supphaprasitt; Lalita Charoenmuang; Nuttawut Thuaksuban; Prawichaya Sangsuwan; Narit Leepong; Danaiya Supakanjanakanti; Surapong Vongvatcharanon; Trin Suwanrat; Woraluk Srimanok
Journal:  J Funct Biomater       Date:  2022-07-15

9.  In-situ solvothermal processing of polycaprolactone/hydroxyapatite nanocomposites with enhanced mechanical and biological performance for bone tissue engineering.

Authors:  Saeed Moeini; Mohammad Reza Mohammadi; Abdolreza Simchi
Journal:  Bioact Mater       Date:  2017-04-21
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.