Literature DB >> 12270185

Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.

Steven D Linton1, Donald S Karanewsky, Robert J Ternansky, Joe C Wu, Brian Pham, Lalitha Kodandapani, Robert Smidt, Jose-Luis Diaz, Lawrence C Fritz, Kevin J Tomaselli.   

Abstract

Parallel synthesis was used to explore the SAR of a peptidomimetic caspase inhibitor. The most potent compound had nanomolar activity against caspases 1, 3, 6, 7, and 8.

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Year:  2002        PMID： 12270185     DOI： 10.1016/s0960-894x(02)00629-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Small Molecule Active Site Directed Tools for Studying Human Caspases.

Authors:  Marcin Poreba; Aleksandra Szalek; Paulina Kasperkiewicz; Wioletta Rut; Guy S Salvesen; Marcin Drag
Journal:  Chem Rev       Date:  2015-11-09       Impact factor: 60.622

Review 2.  Pharmacological neuroprotection for glaucoma.

Authors:  Glyn Chidlow; John P M Wood; Robert J Casson
Journal:  Drugs       Date:  2007       Impact factor: 9.546

3.  MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity.

Authors:  Wu Yang; John Guastella; Jin-Cheng Huang; Yan Wang; Li Zhang; Dong Xue; Minhtam Tran; Richard Woodward; Shailaja Kasibhatla; Ben Tseng; John Drewe; Sui Xiong Cai
Journal:  Br J Pharmacol       Date:  2003-08-26       Impact factor: 8.739

4.  De Novo Molecular Design of Caspase-6 Inhibitors by a GRU-Based Recurrent Neural Network Combined with a Transfer Learning Approach.

Authors:  Shuheng Huang; Hu Mei; Laichun Lu; Minyao Qiu; Xiaoqi Liang; Lei Xu; Zuyin Kuang; Yu Heng; Xianchao Pan
Journal:  Pharmaceuticals (Basel)       Date:  2021-11-30
  4 in total

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