Literature DB >> 12242052

Mildronate: cardioprotective action through carnitine-lowering effect.

Maija Dambrova1, Edgars Liepinsh, Ivars Kalvinsh.   

Abstract

Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myocardial energy metabolism. Biochemical and pharmacological evidence supports the hypothesis that the mechanism of action of mildronate is based on its regulatory effect on carnitine concentration, whereby mildronate treatment shifts the myocardial energy metabolism from fatty acid oxidation to the more favorable glucose oxidation under ischemic conditions. Because mildronate treatment prepares cellular metabolism and membrane structures to survive ischemic stress conditions, it is possible that mildronate could be regarded as an agent of pharmacological preconditioning.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12242052     DOI： 10.1016/s1050-1738(02)00175-5

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  20 in total

1.  Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction.

Authors:  E Liepinsh; M Makrecka-Kuka; J Kuka; R Vilskersts; E Makarova; H Cirule; E Loza; D Lola; S Grinberga; O Pugovics; I Kalvins; M Dambrova
Journal:  Br J Pharmacol       Date:  2015-01-12       Impact factor: 8.739

2.  Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds.

Authors:  Kai-Hsuan Chang; Oliver N F King; Anthony Tumber; Esther C Y Woon; Tom D Heightman; Michael A McDonough; Christopher J Schofield; Nathan R Rose
Journal:  ChemMedChem       Date:  2011-03-15       Impact factor: 3.466

3.  Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae.

Authors:  Gints Kalnins; Janis Kuka; Solveiga Grinberga; Marina Makrecka-Kuka; Edgars Liepinsh; Maija Dambrova; Kaspars Tars
Journal:  J Biol Chem       Date:  2015-07-17       Impact factor: 5.157

4.  Selective regulation of cardiac organic cation transporter novel type 2 (OCTN2) in dilated cardiomyopathy.

Authors:  Markus Grube; Sabine Ameling; Michel Noutsias; Kathleen Köck; Ivonne Triebel; Karina Bonitz; Konrad Meissner; Gabriele Jedlitschky; Lars R Herda; Markus Reinthaler; Maria Rohde; Wolfgang Hoffmann; Uwe Kühl; Heinz-Peter Schultheiss; Uwe Völker; Stephan B Felix; Karin Klingel; Reinhard Kandolf; Heyo K Kroemer
Journal:  Am J Pathol       Date:  2011-06       Impact factor: 4.307

Review 5.  Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency.

Authors:  Robert Ringseis; Janine Keller; Klaus Eder
Journal:  Eur J Nutr       Date:  2011-12-02       Impact factor: 5.614

6.  Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase.

Authors:  Anna M Rydzik; Rasheduzzaman Chowdhury; Grazyna T Kochan; Sophie T Williams; Michael A McDonough; Akane Kawamura; Christopher J Schofield
Journal:  Chem Sci       Date:  2014-05-01       Impact factor: 9.825

7.  Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.

Authors:  Edgars Liepinsh; Elina Skapare; Janis Kuka; Marina Makrecka; Helena Cirule; Edijs Vavers; Eduards Sevostjanovs; Solveiga Grinberga; Osvalds Pugovics; Maija Dambrova
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-03-26       Impact factor: 3.000

8.  Fatty acid synthesis and oxidation in cumulus cells support oocyte maturation in bovine.

Authors:  Laura Sanchez-Lazo; Daphné Brisard; Sébastien Elis; Virginie Maillard; Rustem Uzbekov; Valérie Labas; Alice Desmarchais; Pascal Papillier; Philippe Monget; Svetlana Uzbekova
Journal:  Mol Endocrinol       Date:  2014-07-24

9.  The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila.

Authors:  Shree Ram Singh; Xiankun Zeng; Jiangsha Zhao; Ying Liu; Gerald Hou; Hanhan Liu; Steven X Hou
Journal:  Nature       Date:  2016-09-28       Impact factor: 49.962

10.  The methylester of gamma-butyrobetaine, but not gamma-butyrobetaine itself, induces muscarinic receptor-dependent vasodilatation.

Authors:  Maija Dambrova; Stefan Chlopicki; Edgars Liepinsh; Olga Kirjanova; Olga Gorshkova; Valery I Kozlovski; Staffan Uhlen; Inta Liepina; Ramona Petrovska; Ivars Kalvinsh
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-04-02       Impact factor: 3.000
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.