OBJECTIVES: p27 is a cyclin-dependent kinase inhibitor and a putative tumor suppressor preventing progression of the cell cycle from G1 phase. Recent studies have suggested loss of p27 to correlate with poor prognosis in patients with a variety of solid tumors. Results in gastric cancer are contradictory. We therefore decided to study the potential of p27 as a prognostic marker in a consecutively surgically treated, single-institution series of patients. METHODS: Using a monoclonal antibody against p27, immunohistochemistry was performed in paraffin-embedded tumor specimens from 316 patients. RESULTS: Loss of p27 immunoreactivity (< or = 5% of the cancer cell nuclei positive) was observed in 241 (76%) out of 316 stained tumors. We observed no significant correlation between the expression of p27 and stage of disease, tumor size, depth of tumor invasion, lymph node metastases, distant metastases, Laurén classification, Borrmann type, grade of differentiation, age or gender. There was no significant difference in gastric cancer specific overall survival between patients with low and high p27 expression. CONCLUSION: Our results add further doubt to the usefulness of p27 as a prognostic marker in gastric cancer. Copyright 2002 S. Karger AG, Basel
OBJECTIVES:p27 is a cyclin-dependent kinase inhibitor and a putative tumor suppressor preventing progression of the cell cycle from G1 phase. Recent studies have suggested loss of p27 to correlate with poor prognosis in patients with a variety of solid tumors. Results in gastric cancer are contradictory. We therefore decided to study the potential of p27 as a prognostic marker in a consecutively surgically treated, single-institution series of patients. METHODS: Using a monoclonal antibody against p27, immunohistochemistry was performed in paraffin-embedded tumor specimens from 316 patients. RESULTS: Loss of p27 immunoreactivity (< or = 5% of the cancer cell nuclei positive) was observed in 241 (76%) out of 316 stained tumors. We observed no significant correlation between the expression of p27 and stage of disease, tumor size, depth of tumor invasion, lymph node metastases, distant metastases, Laurén classification, Borrmann type, grade of differentiation, age or gender. There was no significant difference in gastric cancer specific overall survival between patients with low and high p27 expression. CONCLUSION: Our results add further doubt to the usefulness of p27 as a prognostic marker in gastric cancer. Copyright 2002 S. Karger AG, Basel
Authors: Mihaela Chivu-Economescu; Denisa L Dragu; Laura G Necula; Lilia Matei; Ana Maria Enciu; Coralia Bleotu; Carmen C Diaconu Journal: Gastric Cancer Date: 2017-03-15 Impact factor: 7.370
Authors: Stefania Nobili; Lorenzo Bruno; Ida Landini; Cristina Napoli; Paolo Bechi; Francesco Tonelli; Carlos A Rubio; Enrico Mini; Gabriella Nesi Journal: World J Gastroenterol Date: 2011-01-21 Impact factor: 5.742
Authors: Jean M Butte; Javiera Torres; Emanuela F Veras; Kenichi Matsuo; Mithat Gönen; Michael I D'Angelica; Enrique Waugh; Manuel Meneses; Yoshiyaki Inayama; Yuman Fong; Ronald P Dematteo; Hernan De La Fuente; Itaru Endo; David S Klimstra; William R Jarnagin Journal: Ann Surg Oncol Date: 2012-12-01 Impact factor: 5.344
Authors: Q Zhang; D Hou; Z Luo; P Chen; B Lv; L Wu; Y Ma; Y Chu; H Liu; F Liu; S Yu; J Zhang; D Yang; J Liu Journal: Cell Death Dis Date: 2015-08-27 Impact factor: 8.469
Authors: S-J Kim; H-W Lee; H Gu Kang; S-H La; Il Ju Choi; J Y Ro; R S Bresalier; J Song; K-H Chun Journal: Cell Death Differ Date: 2014-06-27 Impact factor: 15.828