Literature DB >> 12239332

Human herpesvirus 8 gene encodes a functional thymidylate synthase.

Gábor Gáspár1, Erik De Clercq, Johan Neyts.   

Abstract

We demonstrate that human herpesvirus 8, obtained from the lymphoma cell line BC-3 as well as from Kaposi's sarcoma lesions, carries a gene that encodes a functional thymidylate synthase (TS). The particular characteristics of this enzyme are studied and compared to the characteristics of TSs encoded by other organisms.

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Year:  2002        PMID： 12239332      PMCID： PMC136588          DOI： 10.1128/jvi.76.20.10530-10532.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

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Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

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10.  Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase.

Authors:  D B Lackey; M P Groziak; M Sergeeva; M Beryt; C Boyer; R M Stroud; P Sayre; J W Park; P Johnston; D Slamon; H M Shepard; M Pegram
Journal:  Biochem Pharmacol       Date:  2001-01-15       Impact factor: 5.858
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5.  Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57.

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6.  Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.

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  6 in total

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