Literature DB >> 12234863

Efficacy of linezolid against methicillin-resistant or vancomycin-insensitive Staphylococcus aureus in a model of hematogenous pulmonary infection.

Katsunori Yanagihara1, Yukihiro Kaneko, Toyomitsu Sawai, Yoshitsugu Miyazaki, Kazuhiro Tsukamoto, Yoichi Hirakata, Kazunori Tomono, Jun-Ichi Kadota, Takayoshi Tashiro, Ikuo Murata, Shigeru Kohno.   

Abstract

We investigated the activities of linezolid, vancomycin, and teicoplanin in a murine model of hematogenous pulmonary infection with Staphylococcus aureus. Our results demonstrate that linezolid clearly reduced bacterial numbers in the methicillin-resistant S. aureus hematogenous infection model and significantly improved the survival rate of immunocompromised mice infected with vancomycin-insensitive S. aureus compared with vancomycin and teicoplanin. The pharmacokinetic profiles also reflected the effectiveness of linezolid.

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Year:  2002        PMID： 12234863      PMCID： PMC128786          DOI： 10.1128/AAC.46.10.3288-3291.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography.

Authors:  G W Peng; R P Stryd; S Murata; M Igarashi; K Chiba; H Aoyama; M Aoyama; T Zenki; N Ozawa
Journal:  J Pharm Biomed Anal       Date:  1999-06       Impact factor: 3.935

2.  Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.

Authors:  K Hiramatsu; H Hanaki; T Ino; K Yabuta; T Oguri; F C Tenover
Journal:  J Antimicrob Chemother       Date:  1997-07       Impact factor: 5.790

3.  Evaluation of Innofluor fluorescence polarization immunoassay kits for the determination of serum concentrations of gentamicin, tobramycin, amikacin and vancomycin.lesassays@ukneqasaa.win-uk.net.

Authors:  L O White; H A Holt; D S Reeves; A P MacGowan
Journal:  J Antimicrob Chemother       Date:  1997-03       Impact factor: 5.790

4.  Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections.

Authors:  J W Chien; M L Kucia; R A Salata
Journal:  Clin Infect Dis       Date:  2000-01       Impact factor: 9.079

5.  Efficacy of linezolid in treatment of experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.

Authors:  C F Dailey; C L Dileto-Fang; L V Buchanan; M P Oramas-Shirey; D H Batts; C W Ford; J K Gibson
Journal:  Antimicrob Agents Chemother       Date:  2001-08       Impact factor: 5.191

6.  Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads.

Authors:  T Sawai; K Tomono; K Yanagihara; Y Yamamoto; M Kaku; Y Hirakata; H Koga; T Tashiro; S Kohno
Journal:  Infect Immun       Date:  1997-02       Impact factor: 3.441

7.  Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group.

Authors:  T L Smith; M L Pearson; K R Wilcox; C Cruz; M V Lancaster; B Robinson-Dunn; F C Tenover; M J Zervos; J D Band; E White; W R Jarvis
Journal:  N Engl J Med       Date:  1999-02-18       Impact factor: 91.245

8.  Clinical evaluation of teicoplanin fluorescence polarization immunoassay.

Authors:  M J Rybak; E M Bailey; V N Reddy
Journal:  Antimicrob Agents Chemother       Date:  1991-08       Impact factor: 5.191
  8 in total
  13 in total

1.  Virulence-suppressing effects of linezolid on methicillin-resistant Staphylococcus aureus: possible contribution to early defervescence.

Authors:  Sadako Yoshizawa; Kazuhiro Tateda; Tomoo Saga; Yoshikazu Ishii; Keizo Yamaguchi
Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

2.  Effect of linezolid on the 50% lethal dose and 50% protective dose in treatment of infections by Gram-negative pathogens in naive and immunosuppressed mice and on the efficacy of ciprofloxacin in an acute murine model of septicemia.

Authors:  Andrea Marra; Lucinda Lamb; Ivette Medina; David George; Glenn Gibson; Joel Hardink; Jady Rugg; Jeffrey Van Deusen; John P O'Donnell
Journal:  Antimicrob Agents Chemother       Date:  2012-06-18       Impact factor: 5.191

Review 3.  The Role of Antibiotics in Modulating Virulence in Staphylococcus aureus.

Authors:  Elisabeth Hodille; Warren Rose; Binh An Diep; Sylvain Goutelle; Gerard Lina; Oana Dumitrescu
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

4.  Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia.

Authors:  Binh An Diep; Anna Afasizheva; Hoan N Le; Osamu Kajikawa; Gustavo Matute-Bello; Christine Tkaczyk; Bret Sellman; Cedric Badiou; Gerard Lina; Henry F Chambers
Journal:  J Infect Dis       Date:  2013-03-26       Impact factor: 5.226

5.  Effects of DQ-113, a new quinolone, against methicillin- and vancomycin-resistant Staphylococcus aureus-caused hematogenous pulmonary infections in mice.

Authors:  Yukihiro Kaneko; Katsunori Yanagihara; Yoshitsugu Miyazaki; Kazuhiro Tsukamoto; Yoichi Hirakata; Kazunori Tomono; Jun-ichi Kadota; Takayoshi Tashiro; Ikuo Murata; Shigeru Kohno
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

6.  Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.

Authors:  Rie Kihara; Katsunori Yanagihara; Yoshitomo Morinaga; Nobuko Araki; Shigeki Nakamura; Masafumi Seki; Koichi Izumikawa; Hiroshi Kakeya; Yoshihiro Yamamoto; Kazuhiro Tsukamoto; Shimeru Kamihira; Shigeru Kohno
Journal:  Antimicrob Agents Chemother       Date:  2008-04-07       Impact factor: 5.191

7.  Activity of tedizolid (TR-700) against well-characterized methicillin-resistant Staphylococcus aureus strains of diverse epidemiological origins.

Authors:  Kenneth S Thomson; Richard V Goering
Journal:  Antimicrob Agents Chemother       Date:  2013-04-09       Impact factor: 5.191

Review 8.  Linezolid effects on bacterial toxin production and host immune response: review of the evidence.

Authors:  Binh An Diep; Ozlem Equils; David B Huang; Ron Gladue
Journal:  Curr Ther Res Clin Exp       Date:  2012-06

9.  Linezolid is superior to vancomycin in experimental pneumonia caused by Superantigen-Producing staphylococcus aureus in HLA class II transgenic mice.

Authors:  Melissa J Karau; Ashenafi Y Tilahun; Suzannah M Schmidt; Chad R Clark; Robin Patel; Govindarajan Rajagopalan
Journal:  Antimicrob Agents Chemother       Date:  2012-07-30       Impact factor: 5.191

10.  Effects of vitamin b6 therapy for sepsis patients with linezolid-associated cytopenias: a retrospective study.

Authors:  Jie Deng; Long-Xiang Su; Zhi-Xin Liang; Li-Ling Liang; Peng Yan; Yan-Hong Jia; Xin-Gang Zhang; Dan Feng; Li-Xin Xie
Journal:  Curr Ther Res Clin Exp       Date:  2013-06
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