BACKGROUND: We encountered on seven malignant hepatocellular tumors developing in older children and adolescents. RESULTS: These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis. CONCLUSION: We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions. Copyright 2002 Wiley-Liss, Inc.
BACKGROUND: We encountered on seven malignant hepatocellular tumors developing in older children and adolescents. RESULTS: These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis. CONCLUSION: We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions. Copyright 2002 Wiley-Liss, Inc.
Authors: Estella M Alonso; Vicky L Ng; Ravinder Anand; Christopher D Anderson; Udeme D Ekong; Emily M Fredericks; Katryn N Furuya; Nitika A Gupta; Stacee M Lerret; Shikha Sundaram; Greg Tiao Journal: Pediatr Transplant Date: 2013-05-30
Authors: Roberta Angelico; Chiara Grimaldi; Maria Cristina Saffioti; Aurora Castellano; Marco Spada Journal: Transl Gastroenterol Hepatol Date: 2018-09-10