Literature DB >> 12226743

A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study.

Stanislaw Winiarczyk1, Zbigniew Gradski, Barbara Kosztolich, Cornelia Gabler, Gerhardt König, Matthias Renner, Robert M Saller, Heinrich Prosl, Brian Salmons, Walter H Günzburg, Johannes Hain.   

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Year:  2002        PMID： 12226743     DOI： 10.1007/s00109-002-0356-0

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


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  10 in total

1.  Development of cellulose sulfate-based polyelectrolyte complex microcapsules for medical applications.

Authors:  H Dautzenberg; U Schuldt; G Grasnick; P Karle; P Müller; M Löhr; M Pelegrin; M Piechaczyk; K V Rombs; W H Günzburg; B Salmons; R M Saller
Journal:  Ann N Y Acad Sci       Date:  1999-06-18       Impact factor: 5.691

2.  Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced-stage pancreatic carcinoma: a phase I/II study.

Authors:  M Löhr; Z T Bago; H Bergmeister; M Ceijna; M Freund; W Gelbmann; W H Günzburg; R Jesnowski; J Hain; K Hauenstein; W Henninger; A Hoffmeyer; P Karle; J C Kröger; G Kundt; S Liebe; U Losert; P Müller; A Probst; K Püschel; M Renner; R Renz; R Saller; B Salmons; I Walter
Journal:  J Mol Med (Berl)       Date:  1999-04       Impact factor: 4.599

3.  Adjuvant post-operative chemotherapy in bitches with mammary cancer.

Authors:  M Karayannopoulou; E Kaldrymidou; T C Constantinidis; A Dessiris
Journal:  J Vet Med A Physiol Pathol Clin Med       Date:  2001-03

4.  Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat.

Authors:  S Genka; J Deutsch; P L Stahle; U H Shetty; V John; C Robinson; S I Rapoport; N H Greig
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

5.  Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma.

Authors:  M Löhr; A Hoffmeyer; J Kröger; M Freund; J Hain; A Holle; P Karle; W T Knöfel; S Liebe; P Müller; H Nizze; M Renner; R M Saller; T Wagner; K Hauenstein; W H Günzburg; B Salmons
Journal:  Lancet       Date:  2001-05-19       Impact factor: 79.321

Review 6.  Factors influencing the incidence and prognosis of canine mammary tumours.

Authors:  M D Perez Alenza; L Peña; N del Castillo; A I Nieto
Journal:  J Small Anim Pract       Date:  2000-07       Impact factor: 1.522

7.  Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.

Authors:  T Kammertoens; W Gelbmann; P Karle; K Alton; R Saller; B Salmons; W H Günzburg; W Uckert
Journal:  Cancer Gene Ther       Date:  2000-04       Impact factor: 5.987

8.  Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450.

Authors:  M Löhr; P Müller; P Karle; J Stange; S Mitzner; R Jesnowski; H Nizze; B Nebe; S Liebe; B Salmons; W H Günzburg
Journal:  Gene Ther       Date:  1998-08       Impact factor: 5.250

9.  Characterization of a human cell clone expressing cytochrome P450 for safe use in human somatic cell therapy.

Authors:  W H Günzburg; P Karle; R Renz; B Salmons; M Renner
Journal:  Ann N Y Acad Sci       Date:  1999-06-30       Impact factor: 5.691

Review 10.  The increasing efficacy of breast cancer treatment.

Authors:  A Gordon
Journal:  Clin Oncol (R Coll Radiol)       Date:  1997       Impact factor: 4.126
  10 in total
  3 in total

Review 1.  Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer.

Authors:  J Matthias Löhr; Stephan L Haas; Jens C Kröger; Helmut M Friess; Raimund Höft; Peter E Goretzki; Christian Peschel; Markus Schweigert; Brian Salmons; Walter H Gunzburg
Journal:  Pharmaceutics       Date:  2014-08-11       Impact factor: 6.321

2.  Phase I/II clinical trial of encapsulated, cytochrome P450 expressing cells as local activators of cyclophosphamide to treat spontaneous canine tumours.

Authors:  Monika Michałowska; Stanislaw Winiarczyk; Łukasz Adaszek; Wojciech Łopuszyński; Zbigniew Grądzki; Brian Salmons; Walter H Günzburg
Journal:  PLoS One       Date:  2014-07-16       Impact factor: 3.240

3.  Efficient protection of microorganisms for delivery to the intestinal tract by cellulose sulphate encapsulation.

Authors:  Walter H Gunzburg; Myo Myint Aung; Pauline Toa; Shirelle Ng; Eliot Read; Wee Jin Tan; Eva Maria Brandtner; John Dangerfield; Brian Salmons
Journal:  Microb Cell Fact       Date:  2020-11-26       Impact factor: 5.328
  3 in total

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