Literature DB >> 10353444

Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced-stage pancreatic carcinoma: a phase I/II study.

M Löhr1, Z T Bago, H Bergmeister, M Ceijna, M Freund, W Gelbmann, W H Günzburg, R Jesnowski, J Hain, K Hauenstein, W Henninger, A Hoffmeyer, P Karle, J C Kröger, G Kundt, S Liebe, U Losert, P Müller, A Probst, K Püschel, M Renner, R Renz, R Saller, B Salmons, I Walter.   

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Year:  1999        PMID： 10353444     DOI： 10.1007/s001090050366

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


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  5 in total

1.  A clinical protocol for treatment of canine mammary tumors using encapsulated, cytochrome P450 synthesizing cells activating cyclophosphamide: a phase I/II study.

Authors:  Stanislaw Winiarczyk; Zbigniew Gradski; Barbara Kosztolich; Cornelia Gabler; Gerhardt König; Matthias Renner; Robert M Saller; Heinrich Prosl; Brian Salmons; Walter H Günzburg; Johannes Hain
Journal:  J Mol Med (Berl)       Date:  2002-06-28       Impact factor: 4.599

Review 2.  Engineering the next generation of cell-based therapeutics.

Authors:  Caleb J Bashor; Isaac B Hilton; Hozefa Bandukwala; Devyn M Smith; Omid Veiseh
Journal:  Nat Rev Drug Discov       Date:  2022-05-30       Impact factor: 112.288

3.  Isolation of human foetal myoblasts and its application for microencapsulation.

Authors:  Anna Aihua Li; Jacqueline Bourgeois; Murray Potter; Patricia L Chang
Journal:  J Cell Mol Med       Date:  2008 Jan-Feb       Impact factor: 5.310

Review 4.  Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: data from two clinical trials in pancreatic cancer.

Authors:  J Matthias Löhr; Stephan L Haas; Jens C Kröger; Helmut M Friess; Raimund Höft; Peter E Goretzki; Christian Peschel; Markus Schweigert; Brian Salmons; Walter H Gunzburg
Journal:  Pharmaceutics       Date:  2014-08-11       Impact factor: 6.321

5.  Phase I/II clinical trial of encapsulated, cytochrome P450 expressing cells as local activators of cyclophosphamide to treat spontaneous canine tumours.

Authors:  Monika Michałowska; Stanislaw Winiarczyk; Łukasz Adaszek; Wojciech Łopuszyński; Zbigniew Grądzki; Brian Salmons; Walter H Günzburg
Journal:  PLoS One       Date:  2014-07-16       Impact factor: 3.240
  5 in total

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