| Literature DB >> 12221601 |
JunSung Lee1, ByungSun Min, SangMyung Lee, MinKyun Na, ByungMok Kwon, ChongOck Lee, YoungHo Kim, KiHwan Bae.
Abstract
Eight sesquiterpene lactones, 4 alpha,5 alpha-epoxy-10 alpha,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), carpesiolin (3), carabrone (4), carabrol (5), telekin (6), ivalin (7) and 11,13-didehydroivaxillin (8), were isolated from the aerial parts of Carpesium abrotanoides Linne (Compositae). In vitro cytotoxicity testing was carried out against L1210, A549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 tumor cell lines. Sesquiterpene lactone compounds 1 - 8 showed significant cytotoxic activity (ED50 values, < 20 microM) against all tumor call lines tested. Among these compounds, 4 alpha,5 alpha-epoxy-10 alpha,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), telekin (6) and ivalin (7) showed cytotoxic activity (ED50, < 10 microM) comparable to that of cisplatin.Entities:
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Year: 2002 PMID： 12221601 DOI： 10.1055/s-2002-33789
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352