Literature DB >> 12220660

Comparative characterization of Aedes 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase and Drosophila serine pyruvate aminotransferase.

Qian Han1, Jianyong Li.   

Abstract

This study describes the comparative analysis of two insect recombinant aminotransferases, Aedes aegypti 3-hydroxykynurenine (3-HK) transaminase/alanine glyoxylate aminotransferase (Ae-HKT/AGT) and Drosophila melanogaster serine pyruvate aminotransferase (Dm-Spat), which share 52% identity in their amino acid sequences. Both enzymes showed AGT activity. In addition, Ae-HKT/AGT is also able to catalyze the transamination of 3-HK or kynurenine with glyoxylate, pyruvate or oxaloacetate as the amino acceptor. Kinetic analysis and other data suggest that Ae-HKT/AGT plays a critical role in mosquito tryptophan catabolism by detoxifying 3-HK and that Dm-Spat is primarily involved in glyoxylate detoxification.

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Year:  2002        PMID： 12220660      PMCID： PMC2857927          DOI： 10.1016/s0014-5793(02)03229-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  HPLC method for analysis of free amino acids in fish using o-phthaldialdehyde precolumn derivatization.

Authors:  F R Antoine; C I Wei; R C Littell; M R Marshall
Journal:  J Agric Food Chem       Date:  1999-12       Impact factor: 5.279

2.  Cloning of rat and human kynurenine aminotransferase.

Authors:  M Mosca; L Cozzi; J Breton; N Avanzi; S Toma; E Okuno; R Schwarcz; C Speciale; S Magagnin; M Mostardini; L Benatti
Journal:  Adv Exp Med Biol       Date:  1996       Impact factor: 2.622

3.  Targeting of alanine: glyoxylate aminotransferase in normal individuals and its mistargeting in patients with primary hyperoxaluria type 1.

Authors:  C J Danpure; P R Jennings; J M Leiper; M J Lumb; P B Oatey
Journal:  Ann N Y Acad Sci       Date:  1996-12-27       Impact factor: 5.691

4.  Peroxisomal alanine : glyoxylate aminotransferase (AGT1) is a photorespiratory enzyme with multiple substrates in Arabidopsis thaliana.

Authors:  A H Liepman; L J Olsen
Journal:  Plant J       Date:  2001-03       Impact factor: 6.417

5.  3-Hydroxykynurenine transaminase identity with alanine glyoxylate transaminase. A probable detoxification protein in Aedes aegypti.

Authors:  Qian Han; Jianmin Fang; Jianyong Li
Journal:  J Biol Chem       Date:  2002-03-05       Impact factor: 5.157

6.  Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase.

Authors:  Q Han; J Fang; J Li
Journal:  Biochem J       Date:  2001-12-15       Impact factor: 3.857

7.  Molecular basis for the dual mitochondrial and cytosolic localization of alanine:glyoxylate aminotransferase in amphibian liver cells.

Authors:  Joanna D Holbrook; Christopher J Danpure
Journal:  J Biol Chem       Date:  2001-11-02       Impact factor: 5.157

8.  Transamination of 3-hydroxykynurenine to produce xanthurenic acid: a major branch pathway of tryptophan metabolism in the mosquito, Aedes aegypti, during larval development.

Authors:  J Li; G Li
Journal:  Insect Biochem Mol Biol       Date:  1997-10       Impact factor: 4.714

Review 9.  Alanine glyoxylate aminotransferase deficiency: biochemical and molecular genetic lessons from the study of a human disease.

Authors:  R W Watts
Journal:  Adv Enzyme Regul       Date:  1992

10.  Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney.

Authors:  R Buchli; D Alberati-Giani; P Malherbe; C Köhler; C Broger; A M Cesura
Journal:  J Biol Chem       Date:  1995-12-08       Impact factor: 5.157
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  9 in total

1.  Evolution of two alanine glyoxylate aminotransferases in mosquito.

Authors:  Qian Han; Seong Ryul Kim; Haizhen Ding; Jianyong Li
Journal:  Biochem J       Date:  2006-08-01       Impact factor: 3.857

2.  Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation.

Authors:  Junsuo S Li; Qian Han; Jianmin Fang; Menico Rizzi; Anthony A James; Jianyong Li
Journal:  Arch Insect Biochem Physiol       Date:  2007-02       Impact factor: 1.698

3.  Cysteine and keto acids modulate mosquito kynurenine aminotransferase catalyzed kynurenic acid production.

Authors:  Qian Han; Jianyong Li
Journal:  FEBS Lett       Date:  2004-11-19       Impact factor: 4.124

4.  Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase.

Authors:  Franca Rossi; Silvia Garavaglia; Giovanni Battista Giovenzana; Bruno Arcà; Jianyong Li; Menico Rizzi
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-03       Impact factor: 11.205

5.  The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis.

Authors:  Qian Han; Brenda T Beerntsen; Jianyong Li
Journal:  J Insect Physiol       Date:  2006-09-17       Impact factor: 2.354

6.  Detoxification and stress response genes expressed in a western North American bumble bee, Bombus huntii (Hymenoptera: Apidae).

Authors:  Junhuan Xu; James P Strange; Dennis L Welker; Rosalind R James
Journal:  BMC Genomics       Date:  2013-12-12       Impact factor: 3.969

Review 7.  Insect Arylalkylamine N-Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis.

Authors:  Brian G O'Flynn; Gabriela Suarez; Aidan J Hawley; David J Merkler
Journal:  Front Mol Biosci       Date:  2018-07-26

8.  Biochemical Evolution of a Potent Target of Mosquito Larvicide, 3-Hydroxykynurenine Transaminase.

Authors:  Huaqing Chen; Biswajit Bhowmick; Yu Tang; Jesus Lozano-Fernandez; Qian Han
Journal:  Molecules       Date:  2022-08-02       Impact factor: 4.927

9.  A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti.

Authors:  Larissa G Maciel; Andrey da S Barbosa; Edilson B de Alencar-Filho; Thereza A Soares; Janaína V Dos Anjos
Journal:  RSC Med Chem       Date:  2020-12-09
  9 in total

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