Literature DB >> 15556614

Cysteine and keto acids modulate mosquito kynurenine aminotransferase catalyzed kynurenic acid production.

Qian Han1, Jianyong Li.   

Abstract

Kynurenine aminotransferase (KAT) catalyzes the formation of kynurenic acid (KYNA), the natural antagonist of ionotropic glutamate receptors. This study tests potential substrates and assesses the effects of amino acids and keto acids on the activity of mosquito KAT. Various keto acids, when simultaneously present in the same reaction mixture, display a combined effect on KAT catalyzed KYNA production. Moreover, methionine and glutamine show inhibitory effects on KAT activity, while cysteine functions as either an antagonist or an inhibitor depending on the concentration. Therefore, the overall level of keto acids and cysteine might modulate the KYNA synthesis. Results from this study will be useful in the study of KAT regulation in other animals.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15556614      PMCID： PMC2855840          DOI： 10.1016/j.febslet.2004.09.088

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  37 in total

Review 1.  Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites.

Authors:  F Moroni
Journal:  Eur J Pharmacol       Date:  1999-06-30       Impact factor: 4.432

Review 2.  Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.

Authors:  T W Stone
Journal:  Trends Pharmacol Sci       Date:  2000-04       Impact factor: 14.819

3.  Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo.

Authors:  H Q Wu; P Guidetti; J H Goodman; M Varasi; G Ceresoli-Borroni; C Speciale; H E Scharfman; R Schwarcz
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590

Review 4.  Differential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminals.

Authors:  M C McKenna; J H Stevenson; X Huang; I B Hopkins
Journal:  Neurochem Int       Date:  2000 Aug-Sep       Impact factor: 3.921

5.  Nicotine-induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid.

Authors:  S Erhardt; M Hajos; A Lindberg; G Engberg
Journal:  Synapse       Date:  2000-08       Impact factor: 2.562

6.  Modulation and function of kynurenic acid in the immature rat brain.

Authors:  R Schwarcz; G Ceresoli-Borroni; H Q Wu; A Rassoulpour; B Poeggeler; P S Hodgkins; P Guidetti
Journal:  Adv Exp Med Biol       Date:  1999       Impact factor: 2.622

7.  Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.

Authors:  A Cozzi; R Carpenedo; F Moroni
Journal:  J Cereb Blood Flow Metab       Date:  1999-07       Impact factor: 6.200

Review 8.  Intercellular metabolic compartmentation in the brain: past, present and future.

Authors:  Leif Hertz
Journal:  Neurochem Int       Date:  2004 Jul-Aug       Impact factor: 3.921

Review 9.  Intracellular metabolic compartmentation assessed by 13C magnetic resonance spectroscopy.

Authors:  Ursula Sonnewald; Arne Schousboe; Hong Qu; Helle S Waagepetersen
Journal:  Neurochem Int       Date:  2004 Jul-Aug       Impact factor: 3.921

Review 10.  The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants.

Authors:  Arthur J L Cooper
Journal:  Neurochem Int       Date:  2004-06       Impact factor: 3.921
View more
  6 in total

Review 1.  Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.

Authors:  Qian Han; Tao Cai; Danilo A Tagle; Jianyong Li
Journal:  Cell Mol Life Sci       Date:  2009-10-15       Impact factor: 9.261

2.  The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis.

Authors:  Qian Han; Brenda T Beerntsen; Jianyong Li
Journal:  J Insect Physiol       Date:  2006-09-17       Impact factor: 2.354

3.  Cloning and molecular characterization of tick kynurenine aminotransferase (HlKAT) from Haemaphysalis longicornis (Acari: Ixodidae).

Authors:  Badgar Battsetseg; Damdinsuren Boldbaatar; Banzragch Battur; Xuenan Xuan; Kozo Fujisaki
Journal:  Parasitol Res       Date:  2009-04-21       Impact factor: 2.289

4.  Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.

Authors:  Qian Han; Howard Robinson; Tao Cai; Danilo A Tagle; Jianyong Li
Journal:  J Med Chem       Date:  2009-05-14       Impact factor: 7.446

5.  Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase.

Authors:  Qian Han; Yi Gui Gao; Howard Robinson; Jianyong Li
Journal:  Biochemistry       Date:  2008-01-11       Impact factor: 3.162

6.  Biochemical and structural properties of mouse kynurenine aminotransferase III.

Authors:  Qian Han; Howard Robinson; Tao Cai; Danilo A Tagle; Jianyong Li
Journal:  Mol Cell Biol       Date:  2008-11-24       Impact factor: 4.272
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.