Literature DB >> 12217359

Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles.

Laura Garuti1, Marinella Roberti, Erik De Clercq.   

Abstract

Some benzimidazolyl sulphones were synthesized and evaluated for their antiviral and antiproliferative properties. Compound 10 displayed significant and selective activity against human cytomegalovirus (CMV), compound 14 showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives. Some structure-activity relationships are discussed.

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Year:  2002        PMID： 12217359     DOI： 10.1016/s0960-894x(02)00535-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones.

Authors:  S Chandrappa; S B Benaka Prasad; K Vinaya; C S Ananda Kumar; N R Thimmegowda; K S Rangappa
Journal:  Invest New Drugs       Date:  2008-05-13       Impact factor: 3.850

2.  1-(1-Benzofuran-2-yl)-2-(phenyl-sulfon-yl)ethanone.

Authors:  Hatem A Abdel-Aziz; Seik Weng Ng; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-17

3.  Synthesis, Crystal Structure, and Spectra Properties of the Cadmium (II) Complex with Bis(N-allylbenzimidazol-2-ylmethyl)benzylamine.

Authors:  Huilu Wu; Jingkun Yuan; Ying Bai; Fan Kou; Fei Jia; Bin Liu
Journal:  Bioinorg Chem Appl       Date:  2011-10-05       Impact factor: 7.778

4.  1-Prop-2-ynyl-1H-benzimidazol-2-amine.

Authors:  Alka Agarwal; Manavendra K Singh; Satish K Awasthi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-11-05

5.  1-(4-Bromo-phen-yl)-2-(phenyl-sulfon-yl)ethanone.

Authors:  Hatem A Abdel-Aziz; Seik Weng Ng; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-14
  5 in total

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