Literature DB >> 12208988

Pregenomic RNA is required for efficient incorporation of pol polyprotein into foamy virus capsids.

Martin Heinkelein1, Cordula Leurs, Matthias Rammling, Katrin Peters, Helmut Hanenberg, Axel Rethwilm.   

Abstract

The foamy virus (FV) Pol polyprotein is translated independently of Gag from a spliced mRNA. This method of expression raises the question of how Pol is associated with the viral particle. Using a transient FV vector transfection system, it is shown that pregenomic RNA is required for efficient virion incorporation of functionally active Pol and that protein-protein interactions of Pol with Gag are not sufficient to complete particle assembly.

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Year:  2002        PMID： 12208988      PMCID： PMC136505          DOI： 10.1128/jvi.76.19.10069-10073.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Complex effects of deletions in the 5' untranslated region of primate foamy virus on viral gene expression and RNA packaging.

Authors:  M Heinkelein; J Thurow; M Dressler; H Imrich; D Neumann-Haefelin; M O McClure; A Rethwilm
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

2.  Expression of human foamy virus reverse transcriptase involves a spliced pol mRNA.

Authors:  I Jordan; J Enssle; E Güttler; B Mauer; A Rethwilm
Journal:  Virology       Date:  1996-10-01       Impact factor: 3.616

3.  Improved primate foamy virus vectors and packaging constructs.

Authors:  Martin Heinkelein; Marco Dressler; Gergely Jármy; Matthias Rammling; Horst Imrich; Jana Thurow; Dirk Lindemann; Axel Rethwilm
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

4.  The carboxyl terminus of the human foamy virus Gag protein contains separable nucleic acid binding and nuclear transport domains.

Authors:  S F Yu; K Edelmann; R K Strong; A Moebes; A Rethwilm; M L Linial
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

5.  Association of murine leukemia virus pol with virions, independent of Gag-Pol expression.

Authors:  G L Buchschacher; L Yu; F Murai; T Friedmann; A Miyanohara
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

6.  Reactivity of primate sera to foamy virus Gag and Bet proteins.

Authors:  H Hahn; G Baunach; S Bräutigam; A Mergia; D Neumann-Haefelin; M D Daniel; M O McClure; A Rethwilm
Journal:  J Gen Virol       Date:  1994-10       Impact factor: 3.891

7.  Human foamy virus replication: a pathway distinct from that of retroviruses and hepadnaviruses.

Authors:  S F Yu; D N Baldwin; S R Gwynn; S Yendapalli; M L Linial
Journal:  Science       Date:  1996-03-15       Impact factor: 47.728

8.  Foamy virus reverse transcriptase is expressed independently from the Gag protein.

Authors:  J Enssle; I Jordan; B Mauer; A Rethwilm
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205

Review 9.  Hepatitis B virus replication.

Authors:  M Nassal; H Schaller
Journal:  Trends Microbiol       Date:  1993-09       Impact factor: 17.079

Review 10.  Particle assembly and genome packaging.

Authors:  M L Linial; S W Eastman
Journal:  Curr Top Microbiol Immunol       Date:  2003       Impact factor: 4.291
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  29 in total

1.  A plant virus replication system to assay the formation of RNA pseudotriloop motifs in RNA-protein interactions.

Authors:  P C Joost Haasnoot; John F Bol; René C L Olsthoorn
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-20       Impact factor: 11.205

2.  Role of the C terminus of foamy virus Gag in RNA packaging and Pol expression.

Authors:  Carolyn R Stenbak; Maxine L Linial
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

3.  Foamy virus Pol protein expressed as a Gag-Pol fusion retains enzymatic activities, allowing for infectious virus production.

Authors:  Eun-Gyung Lee; Amber Sinicrope; Dana L Jackson; Shuyuarn F Yu; Maxine L Linial
Journal:  J Virol       Date:  2012-04-04       Impact factor: 5.103

Review 4.  Molecular biology of foamy viruses.

Authors:  Axel Rethwilm
Journal:  Med Microbiol Immunol       Date:  2010-05-06       Impact factor: 3.402

5.  Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation.

Authors:  Eun-Gyung Lee; Jacqueline Roy; Dana Jackson; Patrick Clark; Paul L Boyer; Stephen H Hughes; Maxine L Linial
Journal:  J Virol       Date:  2010-12-01       Impact factor: 5.103

6.  Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis.

Authors:  Erik Müllers; Tobias Uhlig; Kristin Stirnnagel; Uwe Fiebig; Hanswalter Zentgraf; Dirk Lindemann
Journal:  J Virol       Date:  2010-11-24       Impact factor: 5.103

7.  RNA and protein requirements for incorporation of the Pol protein into foamy virus particles.

Authors:  Katrin Peters; Tatiana Wiktorowicz; Martin Heinkelein; Axel Rethwilm
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

8.  Protease-dependent uncoating of a complex retrovirus.

Authors:  Jacqueline Lehmann-Che; Marie-Lou Giron; Olivier Delelis; Martin Löchelt; Patricia Bittoun; Joelle Tobaly-Tapiero; Hugues de Thé; Ali Saïb
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

9.  Correct capsid assembly mediated by a conserved YXXLGL motif in prototype foamy virus Gag is essential for infectivity and reverse transcription of the viral genome.

Authors:  Ingrid Mannigel; Annett Stange; Hanswalter Zentgraf; Dirk Lindemann
Journal:  J Virol       Date:  2007-01-17       Impact factor: 5.103

10.  The C terminus of foamy retrovirus Gag contains determinants for encapsidation of Pol protein into virions.

Authors:  Eun-Gyung Lee; Maxine L Linial
Journal:  J Virol       Date:  2008-08-20       Impact factor: 5.103
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