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Literature DB >> 12208859

Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8.

Henning Wittenburg¹, Martin C Carey.

Abstract

Entities: Chemical Gene

Mesh：

Substances：

Year: 2002 PMID： 12208859 PMCID： PMC151117 DOI： 10.1172/JCI16548

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

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23 in total

1. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.

Authors: K E Berge; H Tian; G A Graf; L Yu; N V Grishin; J Schultz; P Kwiterovich; B Shan; R Barnes; H H Hobbs
Journal: Science Date: 2000-12-01 Impact factor: 47.728

2. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.

Authors: M H Lee; K Lu; S Hazard; H Yu; S Shulenin; H Hidaka; H Kojima; R Allikmets; N Sakuma; R Pegoraro; A K Srivastava; G Salen; M Dean; S B Patel
Journal: Nat Genet Date: 2001-01 Impact factor: 38.330

3. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.

Authors: K Lu; M H Lee; S Hazard; A Brooks-Wilson; H Hidaka; H Kojima; L Ose; A F Stalenhoef; T Mietinnen; I Bjorkhem; E Bruckert; A Pandya; H B Brewer ; G Salen; M Dean; A Srivastava; S B Patel
Journal: Am J Hum Genet Date: 2001-07-09 Impact factor: 11.025

4. Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: relevance to bile formation and stability.

Authors: K J van Erpecum; M C Carey
Journal: Biochim Biophys Acta Date: 1997-04-21

5. Molecular dynamics simulations of mixed micelles modeling human bile.

Authors: S J Marrink; A E Mark
Journal: Biochemistry Date: 2002-04-30 Impact factor: 3.162

6. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.

Authors: Gregory A Graf; Wei-Ping Li; Robert D Gerard; Ingrid Gelissen; Ann White; Jonathan C Cohen; Helen H Hobbs
Journal: J Clin Invest Date: 2002-09 Impact factor: 14.808

7. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.

Authors: Liqing Yu; Jia Li-Hawkins; Robert E Hammer; Knut E Berge; Jay D Horton; Jonathan C Cohen; Helen H Hobbs
Journal: J Clin Invest Date: 2002-09 Impact factor: 14.808

8. Imaging biliary lipid secretion in the rat: ultrastructural evidence for vesiculation of the hepatocyte canalicular membrane.

Authors: J M Crawford; G M Möckel; A R Crawford; S J Hagen; V C Hatch; S Barnes; J J Godleski; M C Carey
Journal: J Lipid Res Date: 1995-10 Impact factor: 5.922

Review 9. Sitosterolemia.

Authors: G Salen; S Shefer; L Nguyen; G C Ness; G S Tint; V Shore
Journal: J Lipid Res Date: 1992-07 Impact factor: 5.922

10. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse.

Authors: R P Oude Elferink; R Ottenhoff; M van Wijland; J J Smit; A H Schinkel; A K Groen
Journal: J Clin Invest Date: 1995-01 Impact factor: 14.808

20 in total

1. Two Medicago truncatula half-ABC transporters are essential for arbuscule development in arbuscular mycorrhizal symbiosis.

Authors: Quan Zhang; Laura A Blaylock; Maria J Harrison
Journal: Plant Cell Date: 2010-05-07 Impact factor: 11.277

Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8.

1. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.

2. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.

3. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.

4. Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: relevance to bile formation and stability.

5. Molecular dynamics simulations of mixed micelles modeling human bile.

6. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.

7. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.

8. Imaging biliary lipid secretion in the rat: ultrastructural evidence for vesiculation of the hepatocyte canalicular membrane.

Review 9. Sitosterolemia.

10. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse.

1. Two Medicago truncatula half-ABC transporters are essential for arbuscule development in arbuscular mycorrhizal symbiosis.

2. Role of ABC transporters in secretion of cholesterol from liver into bile.

3. Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.

Review 4. ATP-binding cassette, subfamily G (ABCG family).

5. ATP-binding cassette sterol transporters are differentially expressed in normal and diseased human gallbladder.

Review 6. Reverse cholesterol transport: from classical view to new insights.

7. Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice.

Review 8. Genetic defenses against noncholesterol sterols.

9. Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.

10. Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice.