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Literature DB >> 12205444

A reevaluation of integrins as regulators of angiogenesis.

Abstract

Pharmacological agents directed against the integrins alpha(v)beta(3) and alpha(v)beta(5) have been reported to inhibit angiogenesis. However, genetic ablations of the genes encoding these integrins fail to block angiogenesis and in some cases even enhance it. This apparent paradox suggests the hypotheses that these integrins are negative regulators of angiogenesis and that the drugs targeting them may be acting as agonists rather than antagonists.

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Year: 2002 PMID： 12205444 DOI： 10.1038/nm0902-918

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

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Cited

139 in total

1. Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity.

Authors: Ming Yi; Takao Sakai; Reinhard Fassler; Erkki Ruoslahti
Journal: Proc Natl Acad Sci U S A Date: 2003-09-17 Impact factor: 11.205

Review 2. How blood vessel networks are made and measured.

Authors: John C Chappell; David M Wiley; Victoria L Bautch
Journal: Cells Tissues Organs Date: 2011-10-12 Impact factor: 2.481

3. Application of click-click chemistry to the synthesis of new multivalent RGD conjugates.

Authors: Mathieu Galibert; Lucie Sancey; Olivier Renaudet; Jean-Luc Coll; Pascal Dumy; Didier Boturyn
Journal: Org Biomol Chem Date: 2010-09-09 Impact factor: 3.876

4. Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development.

Authors: Arjan van der Flier; Kwabena Badu-Nkansah; Charles A Whittaker; Denise Crowley; Roderick T Bronson; Adam Lacy-Hulbert; Richard O Hynes
Journal: Development Date: 2010-07 Impact factor: 6.868

5. Parameter estimation with a novel gradient-based optimization method for biological lattice-gas cellular automaton models.

Authors: Carsten Mente; Ina Prade; Lutz Brusch; Georg Breier; Andreas Deutsch
Journal: J Math Biol Date: 2010-10-01 Impact factor: 2.259

A reevaluation of integrins as regulators of angiogenesis.

1. Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity.

Review 2. How blood vessel networks are made and measured.

3. Application of click-click chemistry to the synthesis of new multivalent RGD conjugates.

4. Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development.

5. Parameter estimation with a novel gradient-based optimization method for biological lattice-gas cellular automaton models.

Review 6. Neural crest cells and motor axons in avians: Common and distinct migratory molecules.

7. The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand.

8. Dynamic Regulation of Integrin α₆β₄ During Angiogenesis: Potential Implications for Pathogenic Wound Healing.

Review 9. Redox-relevant aspects of the extracellular matrix and its cellular contacts via integrins.

10. Fibronectin fibrillogenesis regulates three-dimensional neovessel formation.