| Literature DB >> 12200547 |
Herve Tettelin1, Vega Masignani, Michael J Cieslewicz, Jonathan A Eisen, Scott Peterson, Michael R Wessels, Ian T Paulsen, Karen E Nelson, Immaculada Margarit, Timothy D Read, Lawrence C Madoff, Alex M Wolf, Maureen J Beanan, Lauren M Brinkac, Sean C Daugherty, Robert T DeBoy, A Scott Durkin, James F Kolonay, Ramana Madupu, Matthew R Lewis, Diana Radune, Nadezhda B Fedorova, David Scanlan, Hoda Khouri, Stephanie Mulligan, Heather A Carty, Robin T Cline, Susan E Van Aken, John Gill, Maria Scarselli, Marirosa Mora, Emilia T Iacobini, Cecilia Brettoni, Giuliano Galli, Massimo Mariani, Filippo Vegni, Domenico Maione, Daniela Rinaudo, Rino Rappuoli, John L Telford, Dennis L Kasper, Guido Grandi, Claire M Fraser.
Abstract
The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.Entities:
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Year: 2002 PMID： 12200547 PMCID： PMC129455 DOI： 10.1073/pnas.182380799
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205