| Literature DB >> 12200157 |
Alfonso Martinez Arias1, Vincent Zecchini, Keith Brennan.
Abstract
During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.Entities:
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Year: 2002 PMID： 12200157 DOI： 10.1016/s0959-437x(02)00336-2
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578