Literature DB >> 12198769

Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis lung carcinoma tumor variants.

Jodi L Jackson1, M Rita I Young.   

Abstract

Cellular adhesion and motility, processes regulated by focal adhesion assembly and disassembly, can influence a tumor cell's ability to metastasize. Focal adhesion dynamics are, in turn, influenced by the serine and tyrosine phosphorylation state of paxillin. Using Lewis lung carcinoma (LLC) tumor variants, this study shows the importance of the serine/threonine protein phosphatase-2A (PP-2A) in maintaining adherence and restricting tumor cell motility, and modulating the serine and tyrosine phosphorylation of paxillin. Treating non-metastatic LLC-C8 tumor variants with okadaic acid to inhibit PP-2A activity resulted in cell rounding and increased motility. These effects on motility and adherence were accompanied by increased serine and decreased tyrosine phosphorylation of paxillin. These results suggest PP-2A regulation of paxillin phosphorylation may have a role in controlling tumor cell adherence and motility.

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Year:  2002        PMID： 12198769     DOI： 10.1023/a:1016385027013

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  33 in total

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Journal:  Mol Biol Cell       Date:  1998-07       Impact factor: 4.138

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Journal:  J Cell Sci       Date:  1978-02       Impact factor: 5.285

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Journal:  J Cell Biol       Date:  1992-11       Impact factor: 10.539
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  8 in total

1.  TGF-beta regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1.

Authors:  Jarrett E Walsh; M Rita I Young
Journal:  Anticancer Res       Date:  2011-10       Impact factor: 2.480

2.  Interrelationship between protein phosphatase 1 and TGF-{beta} in regulating motility and cytoskeletal architecture of endothelial cells.

Authors:  Jarrett E Walsh; M Rita I Young
Journal:  Anticancer Res       Date:  2010-12       Impact factor: 2.480

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Authors:  Alex A Romashko; M Rita I Young
Journal:  Clin Exp Metastasis       Date:  2004       Impact factor: 5.150

4.  Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants.

Authors:  Jodi L Jackson; M Rita I Young
Journal:  Clin Exp Metastasis       Date:  2003       Impact factor: 5.150

5.  Autocrine motility-stimulatory pathways of oral premalignant lesion cells.

Authors:  M Rita I Young; Brad W Neville; Angela C Chi; Deanne M R Lathers; M Boyd Gillespie; Terry A Day
Journal:  Clin Exp Metastasis       Date:  2007-03-17       Impact factor: 4.510

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Authors:  Kaixi Tang; Colton G Boudreau; Claire M Brown; Anmar Khadra
Journal:  PLoS Comput Biol       Date:  2018-07-05       Impact factor: 4.475

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Authors:  Marta Ripamonti; Andrea Lamarca; Norman E Davey; Diletta Tonoli; Sara Surini; Ivan de Curtis
Journal:  Commun Biol       Date:  2022-09-28

8.  Increased Paxillin expression in prostate cancer is associated with advanced pathological features, lymph node metastases and biochemical recurrence.

Authors:  Qing-Shui Zheng; Shao-Hao Chen; Yu-Peng Wu; Hui-Jun Chen; Hong Chen; Yong Wei; Xiao-Dong Li; Jin-Bei Huang; Xue-Yi Xue; Ning Xu
Journal:  J Cancer       Date:  2018-02-28       Impact factor: 4.207
  8 in total

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