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Literature DB >> 11146675

Paxillin and focal adhesion signalling.

Abstract

To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.

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Year: 2000 PMID： 11146675 DOI： 10.1038/35046659

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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Cited

275 in total

1. Further characterization of the interaction between the cytoskeletal proteins talin and vinculin.

Authors: Mark D Bass; Bipin Patel; Igor G Barsukov; Ian J Fillingham; Robert Mason; Beverley J Smith; Clive R Bagshaw; David R Critchley
Journal: Biochem J Date: 2002-03-15 Impact factor: 3.857

2. Approaches to studying cellular signaling: a primer for morphologists.

Authors: Kathy Kay Hartford Svoboda; Wende R Reenstra
Journal: Anat Rec Date: 2002-04-15

3. Cellular signaling during the macrophage invasion by Trypanosoma cruzi.

Authors: Mauricio Vieira; Juliana M F Dutra; Tecia M U Carvalho; Narcisa L Cunha-e-Silva; Thaïs Souto-Padrón; Wanderley Souza
Journal: Histochem Cell Biol Date: 2002-11-23 Impact factor: 4.304

4. Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2.

Authors: Götz von Wichert; Beatrice Haimovich; Gen-Sheng Feng; Michael P Sheetz
Journal: EMBO J Date: 2003-10-01 Impact factor: 11.598

5. Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts.

Authors: Boris Hinz; Vera Dugina; Christoph Ballestrem; Bernhard Wehrle-Haller; Christine Chaponnier
Journal: Mol Biol Cell Date: 2003-02-21 Impact factor: 4.138

6. MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.

Authors: Bruce D Cuevas; Amy N Abell; James A Witowsky; Toshiaki Yujiri; Nancy Lassignal Johnson; Kamala Kesavan; Marti Ware; Peter L Jones; Scott A Weed; Roberta L DeBiasi; Yoshitomo Oka; Kenneth L Tyler; Gary L Johnson
Journal: EMBO J Date: 2003-07-01 Impact factor: 11.598

Paxillin and focal adhesion signalling.

1. Further characterization of the interaction between the cytoskeletal proteins talin and vinculin.

2. Approaches to studying cellular signaling: a primer for morphologists.

3. Cellular signaling during the macrophage invasion by Trypanosoma cruzi.

4. Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2.

5. Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts.

6. MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.

7. alpha4beta1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism.

Review 8. "Looping In" Mechanics: Mechanobiologic Regulation of the Nucleus and the Epigenome.

9. Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity.

10. Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin.