Literature DB >> 12197935

Numerical investigation of the effect of blade geometry on blood trauma in a centrifugal blood pump.

W K Chan1, Y W Wong, Y Ding, L P Chua, S C M Yu.   

Abstract

Fluid dynamic forces in centrifugal blood pump impellers are of key importance in destruction of red blood cells (RBCs) because high rotational speed leads to strong interaction between the impeller and the RBCs. In this paper, three-dimensional models of five different blade geometries are investigated numerically using the commercial software CFX-TASCflow, and the streaklines of RBCs are obtained using the Lagrangian particle tracking method. In reality, RBCs pass through the pump along complicated paths resulting in a highly irregular loading condition for each RBC. In order to enable the prediction of blood damage under the action of these complex-loading conditions, a cumulative damage model for RBCs was adopted in this paper. The numerically simulated percent hemoglobin (%HB) released as RBCs traversed the impeller and volute was examined. It was observed that the residence time of particles in the blade passage is a critical factor in determining hemolytic effects. This, in turn, is a function of the blade geometry. In addition, it was observed that the volute profile is an important influence on the computed HB% released.

Entities:  

Mesh:

Year:  2002        PMID: 12197935     DOI: 10.1046/j.1525-1594.2002.06954.x

Source DB:  PubMed          Journal:  Artif Organs        ISSN: 0160-564X            Impact factor:   3.094


  8 in total

Review 1.  The use of computational fluid dynamics in the development of ventricular assist devices.

Authors:  Katharine H Fraser; M Ertan Taskin; Bartley P Griffith; Zhongjun J Wu
Journal:  Med Eng Phys       Date:  2010-11-13       Impact factor: 2.242

2.  Mechanical platelet activation potential in abdominal aortic aneurysms.

Authors:  Kirk B Hansen; Amirhossein Arzani; Shawn C Shadden
Journal:  J Biomech Eng       Date:  2015-02-05       Impact factor: 2.097

3.  Prediction of mechanical hemolysis in medical devices via a Lagrangian strain-based multiscale model.

Authors:  Mehdi Nikfar; Meghdad Razizadeh; Jiafeng Zhang; Ratul Paul; Zhongjun J Wu; Yaling Liu
Journal:  Artif Organs       Date:  2020-03-05       Impact factor: 3.094

4.  Numerical investigation of the performance of three hinge designs of bileaflet mechanical heart valves.

Authors:  Hélène A Simon; Liang Ge; Fotis Sotiropoulos; Ajit P Yoganathan
Journal:  Ann Biomed Eng       Date:  2010-06-23       Impact factor: 3.934

5.  Computational fluid dynamics-based study of possibility of generating pulsatile blood flow via a continuous-flow VAD.

Authors:  Erfan Nammakie; Hanieh Niroomand-Oscuii; Mojtaba Koochaki; Farzan Ghalichi
Journal:  Med Biol Eng Comput       Date:  2016-05-27       Impact factor: 2.602

6.  Computational fluid dynamics analysis of blade tip clearances on hemodynamic performance and blood damage in a centrifugal ventricular assist device.

Authors:  Jingchun Wu; Bradley E Paden; Harvey S Borovetz; James F Antaki
Journal:  Artif Organs       Date:  2009-10-12       Impact factor: 3.094

7.  Computational modeling of the Food and Drug Administration's benchmark centrifugal blood pump.

Authors:  Bryan C Good; Keefe B Manning
Journal:  Artif Organs       Date:  2020-02-16       Impact factor: 3.094

8.  Computational Parametric Study of the Axial and Radial Clearances in a Centrifugal Rotary Blood Pump.

Authors:  Mohammad Amin Rezaienia; Gordon Paul; Eldad Avital; Martin Rothman; Theodosios Korakianitis
Journal:  ASAIO J       Date:  2018 Sep/Oct       Impact factor: 2.872

  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.