Literature DB >> 12197315

New developments in chemical library synthesis. Norbornenyl tags for use in phase-switching, sequestration, capture-release and soluble support applications.

Daniel L Flynn1, Paul R Hanson, Scott C Berk, Gergely M Makara.   

Abstract

A new, general chemical library purification platform is reviewed. This platform makes broad use of (oxa)norbornenyl-tagged reactants, reagents, catalysts, sequestration-enabling reagents and scavengers, in combination with Grubbs catalyst-mediated ring-opening metathesis polymerization (ROMP) reactions as an in situ polymerization purification technique. Extensions of this platform involve the use of preformed ROMP supports in synthesis, and polystyrene-supported Grubbs catalysts, which perform in a boomerang fashion.

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Year:  2002        PMID： 12197315

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  10 in total

1.  Immobilization on a Nanomagnetic Co/C Surface Using ROM Polymerization: Generation of a Hybrid Material as Support for a Recyclable Palladium Catalyst.

Authors:  Alexander Schätz; Toby R Long; Robert N Grass; Wendelin J Stark; Paul R Hanson; Oliver Reiser
Journal:  Adv Funct Mater       Date:  2010-12-21       Impact factor: 18.808

2.  S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides.

Authors:  Alan Rolfe; Thiwanka B Samarakoon; Sarra V Klimberg; Marek Brzozowski; Benjamin Neuenswander; Gerald H Lushington; Paul R Hanson
Journal:  J Comb Chem       Date:  2010-09-29

3.  Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol.

Authors:  Naeem Asad; Paul R Hanson; Toby R Long; Dinesh K Rayabarapu; Alan Rolfe
Journal:  Chem Commun (Camb)       Date:  2011-07-05       Impact factor: 6.222

4.  ROMP-derived oligomeric phosphates for application in facile benzylation.

Authors:  Toby R Long; Pradip K Maity; Thiwanka B Samarakoon; Paul R Hanson
Journal:  Org Lett       Date:  2010-07-02       Impact factor: 6.005

5.  Silica-Supported Oligomeric Benzyl Phosphate (Si-OBP) and Triazole Phosphate (Si-OTP) Alkylating Reagents.

Authors:  Pradip K Maity; Saqib Faisal; Alan Rolfe; Diana Stoianova; Paul R Hanson
Journal:  J Org Chem       Date:  2015-10-02       Impact factor: 4.354

6.  Monomer-on-monomer (MoM) Mitsunobu reaction: facile purification utilizing surface-initiated sequestration.

Authors:  Pradip K Maity; Alan Rolfe; Thiwanka B Samarakoon; Saqib Faisal; Ryan D Kurtz; Toby R Long; Alexander Schätz; Daniel L Flynn; Robert N Grass; Wendelin J Stark; Oliver Reiser; Paul R Hanson
Journal:  Org Lett       Date:  2010-12-01       Impact factor: 6.005

7.  High-load, hybrid Si-ROMP reagents.

Authors:  Alan Rolfe; Joanna K Loh; Pradip K Maity; Paul R Hanson
Journal:  Org Lett       Date:  2010-12-01       Impact factor: 6.005

8.  "Click"-capture, ring-opening metathesis polymerization (ROMP), release: facile triazolation utilizing ROMP-derived oligomeric phosphates.

Authors:  Toby R Long; Saqib Faisal; Pradip K Maity; Alan Rolfe; Ryan Kurtz; Sarra V Klimberg; Muhammad-Rabbie Najjar; Fatima Z Basha; Paul R Hanson
Journal:  Org Lett       Date:  2011-03-24       Impact factor: 6.005

9.  High-load, oligomeric monoamine hydrochloride: Facile generation via ROM polymerization and application as an electrophile scavenger.

Authors:  Diana S Stoianova; Lei Yao; Alan Rolfe; Thiwanka Samarakoon; Paul R Hanson
Journal:  Tetrahedron Lett       Date:  2008       Impact factor: 2.415

10.  High-load, oligomeric dichlorotriazine: a versatile ROMP-derived reagent and scavenger.

Authors:  Alan Rolfe; Donald A Probst; Kelly A Volp; Iman Omar; Daniel L Flynn; Paul R Hanson
Journal:  J Org Chem       Date:  2008-10-21       Impact factor: 4.354
  10 in total

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