OBJECTIVE: To determine factors influencing the wide variation of protein concentration in lumbar cerebrospinal fluid (CSF). METHODS: Patient variables with potential influence on spinal CSF flow and resorption were measured in different patient settings and compared with albumin and IgG CSF/serum quotients. RESULTS: In patients whose diagnostic lumbar puncture produces normal CSF the albumin quotient increased with body mass index (r = 0.408), abdominal circumference (r = 0.399), and body weight (r = 0.317), age-corrected with partial correlation. Body motion before lumbar puncture showed only marginal influence on albumin quotient. In patients with radiculography the albumin quotient decreased with iodine contrast medium elimination from spinal subarachnoid space (r = -0.598) and increased with narrowing of lumbosacral spinal canal (r = 0.515). CONCLUSION: Correlation of albumin quotient with body mass index and related variables may be mediated by spinal CSF resorption, which should be impaired in overweight patients with elevated venous pressure. Negative correlation of albumin quotient with iodine resorption from spinal CSF supports this assumption. Correlation of albumin quotient with narrowing of lumbosacral canal should be due to slowed spinal CSF flow which does increase protein concentration. Tested variables explain part of variation of CSF protein concentration. Other variables like blood-CSF barrier permeability and pulsatile spinal CSF flow should have additional influence.
OBJECTIVE: To determine factors influencing the wide variation of protein concentration in lumbar cerebrospinal fluid (CSF). METHODS:Patient variables with potential influence on spinal CSF flow and resorption were measured in different patient settings and compared with albumin and IgG CSF/serum quotients. RESULTS: In patients whose diagnostic lumbar puncture produces normal CSF the albumin quotient increased with body mass index (r = 0.408), abdominal circumference (r = 0.399), and body weight (r = 0.317), age-corrected with partial correlation. Body motion before lumbar puncture showed only marginal influence on albumin quotient. In patients with radiculography the albumin quotient decreased with iodine contrast medium elimination from spinal subarachnoid space (r = -0.598) and increased with narrowing of lumbosacral spinal canal (r = 0.515). CONCLUSION: Correlation of albumin quotient with body mass index and related variables may be mediated by spinal CSF resorption, which should be impaired in overweight patients with elevated venous pressure. Negative correlation of albumin quotient with iodine resorption from spinal CSF supports this assumption. Correlation of albumin quotient with narrowing of lumbosacral canal should be due to slowed spinal CSF flow which does increase protein concentration. Tested variables explain part of variation of CSF protein concentration. Other variables like blood-CSF barrier permeability and pulsatile spinal CSF flow should have additional influence.
Authors: Ariane Lewis; Rajan Jain; Jennifer Frontera; Dimitris G Placantonakis; Steven Galetta; Laura Balcer; Kara R Melmed Journal: J Neuroimaging Date: 2021-06-08 Impact factor: 2.324
Authors: Otto Tschritter; Anita M Hennige; Hubert Preissl; Katarina Porubska; Silke A Schäfer; Werner Lutzenberger; Fausto Machicao; Niels Birbaumer; Andreas Fritsche; Hans-Ulrich Häring Journal: PLoS One Date: 2007-11-21 Impact factor: 3.240
Authors: Refik Pul; Özlem Yildiz; Franco Morbiducci; Thomas Skripuletz; Philipp Schwenkenbecher; Martin Stangel; Friedrich Götz; Georg Berding; Corinna Trebst; Frank Donnerstag Journal: Dis Markers Date: 2015-09-10 Impact factor: 3.434