Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness.

Literature DB >> 12194866

Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness.

Genevieve M Kruger¹, Jack T Mosher, Suzanne Bixby, Nancy Joseph, Toshihide Iwashita, Sean J Morrison.

Abstract

We found neural crest stem cells (NCSCs) in the adult gut. Postnatal gut NCSCs were isolated by flow-cytometry and compared to fetal gut NCSCs. They self-renewed extensively in culture but less than fetal gut NCSCs. Postnatal gut NCSCs made neurons that expressed a variety of neurotransmitters but lost the ability to make certain subtypes of neurons that are generated during fetal development. Postnatal gut NCSCs also differed in their responsiveness to lineage determination factors, affecting cell fate determination in vivo and possibly explaining their reduced neuronal subtype potential. These perinatal changes in gut NCSCs parallel perinatal changes in hematopoietic stem cells, suggesting that stem cells in different tissues undergo similar developmental transitions. The persistence of NCSCs in the adult PNS opens up new possibilities for regeneration after injury or disease.

Entities: Disease

Mesh：

Substances：

Year: 2002 PMID： 12194866 PMCID： PMC2728576 DOI： 10.1016/s0896-6273(02)00827-9

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

52 in total

1. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.

Authors: S J Morrison; S E Perez; Z Qiao; J M Verdi; C Hicks; G Weinmaster; D J Anderson
Journal: Cell Date: 2000-05-26 Impact factor: 41.582

2. Isolation of a stem cell for neurons and glia from the mammalian neural crest.

Authors: D L Stemple; D J Anderson
Journal: Cell Date: 1992-12-11 Impact factor: 41.582

3. Nitric oxide synthase-containing neurons in the myenteric plexus of the rat gastrointestinal tract: distribution and regional density.

Authors: M K Jarvinen; W J Wollmann; T A Powrozek; J A Schultz; T L Powley
Journal: Anat Embryol (Berl) Date: 1999-02

4. Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis.

Authors: D A Lim; G J Fishell; A Alvarez-Buylla
Journal: Proc Natl Acad Sci U S A Date: 1997-12-23 Impact factor: 11.205

5. The adult rat hippocampus contains primordial neural stem cells.

Authors: T D Palmer; J Takahashi; F H Gage
Journal: Mol Cell Neurosci Date: 1997 Impact factor: 4.314

6. A series of normal stages in the development of the chick embryo.

Authors: V HAMBURGER; H L HAMILTON
Journal: J Morphol Date: 1951-01 Impact factor: 1.804

7. The alpha4 subunit of integrin is important for neural crest cell migration.

Authors: S H Kil; C E Krull; G Cann; D Clegg; M Bronner-Fraser
Journal: Dev Biol Date: 1998-10-01 Impact factor: 3.582

8. Time of origin of neurons in the murine enteric nervous system: sequence in relation to phenotype.

Authors: T D Pham; M D Gershon; T P Rothman
Journal: J Comp Neurol Date: 1991-12-22 Impact factor: 3.215

9. Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence.

Authors: E Blaugrund; T D Pham; V M Tennyson; L Lo; L Sommer; D J Anderson; M D Gershon
Journal: Development Date: 1996-01 Impact factor: 6.868

10. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.

Authors: K Hayakawa; R R Hardy; L A Herzenberg; L A Herzenberg
Journal: J Exp Med Date: 1985-06-01 Impact factor: 14.307

165 in total

1. Enteric neuronal density contributes to the severity of intestinal inflammation.

Authors: Kara Gross Margolis; Korey Stevanovic; Nima Karamooz; Zi Shan Li; Ankur Ahuja; Fabien D'Autréaux; Virginia Saurman; Alcmene Chalazonitis; Michael David Gershon
Journal: Gastroenterology Date: 2011-04-28 Impact factor: 22.682

2. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.

Authors: Anna V Molofsky; Ricardo Pardal; Toshihide Iwashita; In-Kyung Park; Michael F Clarke; Sean J Morrison
Journal: Nature Date: 2003-10-22 Impact factor: 49.962

3. Hirschsprung disease is linked to defects in neural crest stem cell function.

Authors: Toshihide Iwashita; Genevieve M Kruger; Ricardo Pardal; Mark J Kiel; Sean J Morrison
Journal: Science Date: 2003-08-15 Impact factor: 47.728

Review 4. Neural crest stem cells: discovery, properties and potential for therapy.

Authors: Annita Achilleos; Paul A Trainor
Journal: Cell Res Date: 2012-01-10 Impact factor: 25.617

5. Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors.

Authors: Nathan A Mundell; Jennifer L Plank; Alison W LeGrone; Audrey Y Frist; Lei Zhu; Myung K Shin; E Michelle Southard-Smith; Patricia A Labosky
Journal: Dev Biol Date: 2012-01-12 Impact factor: 3.582

6. Divergent fate and origin of neurosphere-like bodies from different layers of the gut.

Authors: Laren Becker; Subhash Kulkarni; Gunjan Tiwari; Maria-Adelaide Micci; Pankaj Jay Pasricha
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-02-23 Impact factor: 4.052

7. Genetic background impacts developmental potential of enteric neural crest-derived progenitors in the Sox10Dom model of Hirschsprung disease.

Authors: Lauren C Walters; V Ashley Cantrell; Kevin P Weller; Jack T Mosher; E Michelle Southard-Smith
Journal: Hum Mol Genet Date: 2010-08-25 Impact factor: 6.150