Literature DB >> 12194841

The fertile field of Drosophila Jak/STAT signalling.

James Castelli- Gair Hombría1, Stephen Brown.   

Abstract

The JAK/STAT pathway plays important roles in vertebrate and invertebrate development. The recent cloning and characterisation of the receptor in Drosophila shows that the pathway is conserved across phyla. In this review we describe current knowledge of the pathway and use genome data to discuss what elements are present in Drosophila. We also summarise recent work describing the involvement of the JAK/STAT pathway in oogenesis and spermatogenesis. Interestingly, the JAK/STAT pathway maintains the niche required for germline stem cell maintenance in the testis, providing the first molecular characterisation of a stem cell niche. Drosophila's streamlined pathway offers a simple model to find new elements and analyse the function of existing ones.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12194841     DOI： 10.1016/s0960-9822(02)01057-6

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  45 in total

1.  Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila.

Authors:  Tijana Copf; Valérie Goguel; Aurélie Lampin-Saint-Amaux; Niki Scaplehorn; Thomas Preat
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-25       Impact factor: 11.205

Review 2.  Biology and significance of the JAK/STAT signalling pathways.

Authors:  Hiu Kiu; Sandra E Nicholson
Journal:  Growth Factors       Date:  2012-02-20       Impact factor: 2.511

3.  Identification of Drosophila genes modulating Janus kinase/signal transducer and activator of transcription signal transduction.

Authors:  Tina Mukherjee; Ulrich Schäfer; Martin P Zeidler
Journal:  Genetics       Date:  2005-12-30       Impact factor: 4.562

4.  Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly.

Authors:  Michael Field; Patrick S Tarpey; Raffaella Smith; Sarah Edkins; Sarah O'Meara; Claire Stevens; Calli Tofts; Jon Teague; Adam Butler; Ed Dicks; Syd Barthorpe; Gemma Buck; Jennifer Cole; Kristian Gray; Kelly Halliday; Katy Hills; Andrew Jenkinson; David Jones; Andrew Menzies; Tatiana Mironenko; Janet Perry; Keiran Raine; David Richardson; Rebecca Shepherd; Alexandra Small; Jennifer Varian; Sofie West; Sara Widaa; Uma Mallya; Richard Wooster; Jenny Moon; Ying Luo; Helen Hughes; Marie Shaw; Kathryn L Friend; Mark Corbett; Gillian Turner; Michael Partington; John Mulley; Martin Bobrow; Charles Schwartz; Roger Stevenson; Jozef Gecz; Michael R Stratton; P Andrew Futreal; F Lucy Raymond
Journal:  Am J Hum Genet       Date:  2007-06-26       Impact factor: 11.025

Review 5.  Drosophila follicle cells: morphogenesis in an eggshell.

Authors:  Xiaodong Wu; Pradeep Singh Tanwar; Laurel A Raftery
Journal:  Semin Cell Dev Biol       Date:  2008-01-20       Impact factor: 7.727

6.  Drosophila as a model for antiviral immunity.

Authors:  Jing-Huan Wang; Susanna Valanne; Mika Rämet
Journal:  World J Biol Chem       Date:  2010-05-26

7.  Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.

Authors:  Amanda J Monahan; Michelle Starz-Gaiano
Journal:  Dev Biol       Date:  2013-04-10       Impact factor: 3.582

8.  Essential roles for stat92E in expanding and patterning the proximodistal axis of the Drosophila wing imaginal disc.

Authors:  Victor Hatini; Ela Kula-Eversole; David Nusinow; Steven J Del Signore
Journal:  Dev Biol       Date:  2013-03-07       Impact factor: 3.582

9.  A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway.

Authors:  Erika A Bach; Stephane Vincent; Martin P Zeidler; Norbert Perrimon
Journal:  Genetics       Date:  2003-11       Impact factor: 4.562

10.  Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor.

Authors:  M Melissa Gilbert; Carolyn K Beam; Brian S Robinson; Kenneth H Moberg
Journal:  PLoS One       Date:  2009-09-29       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.