Literature DB >> 12186938

The human cytomegalovirus ribonucleotide reductase homolog UL45 is dispensable for growth in endothelial cells, as determined by a BAC-cloned clinical isolate of human cytomegalovirus with preserved wild-type characteristics.

Gabriele Hahn1, Hanna Khan, Fausto Baldanti, Ulrich H Koszinowski, M Grazia Revello, Giuseppe Gerna.   

Abstract

An endothelial cell-tropic and leukotropic human cytomegalovirus (HCMV) clinical isolate was cloned as a fusion-inducing factor X-bacterial artificial chromosome in Escherichia coli, and the ribonucleotide reductase homolog UL45 was deleted. Reconstituted virus RVFIX and RV Delta UL45 grew equally well in human fibroblasts and human endothelial cells. Thus, UL45 is dispensable for growth of HCMV in both cell types.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12186938      PMCID： PMC136448          DOI： 10.1128/jvi.76.18.9551-9555.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

Authors:  V S Goldmacher; L M Bartle; A Skaletskaya; C A Dionne; N L Kedersha; C A Vater; J W Han; R J Lutz; S Watanabe; E D Cahir McFarland; E D Kieff; E S Mocarski; T Chittenden
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

Review 2.  Cytomegalovirus bacterial artificial chromosomes: a new herpesvirus vector approach.

Authors:  M Messerle; G Hahn; W Brune; U H Koszinowski
Journal:  Adv Virus Res       Date:  2000       Impact factor: 9.937

3.  Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes.

Authors:  A Marchini; H Liu; H Zhu
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

4.  Allele replacement: an application that permits rapid manipulation of herpes simplex virus type 1 genomes.

Authors:  B C Horsburgh; M M Hubinette; D Qiang; M L MacDonald; F Tufaro
Journal:  Gene Ther       Date:  1999-05       Impact factor: 5.250

5.  A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism.

Authors:  W Brune; C Ménard; J Heesemann; U H Koszinowski
Journal:  Science       Date:  2001-01-12       Impact factor: 47.728

6.  In vitro selection of human cytomegalovirus variants unable to transfer virus and virus products from infected cells to polymorphonuclear leukocytes and to grow in endothelial cells.

Authors:  M Grazia Revello; Fausto Baldanti; Elena Percivalle; Antonella Sarasini; Luciana De-Giuli; Emilia Genini; Daniele Lilleri; Nazarena Labò; Giuseppe Gerna
Journal:  J Gen Virol       Date:  2001-06       Impact factor: 3.891

7.  Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome.

Authors:  H Adler; M Messerle; M Wagner; U H Koszinowski
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

8.  Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: a new approach for construction of HCMV mutants.

Authors:  E M Borst; G Hahn; U H Koszinowski; M Messerle
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

9.  The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway.

Authors:  D Perkins; E F R Pereira; M Gober; P J Yarowsky; L Aurelian
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

10.  Molecular cloning of the guinea pig cytomegalovirus (GPCMV) genome as an infectious bacterial artificial chromosome (BAC) in Escherichia coli.

Authors:  A McGregor; M R Schleiss
Journal:  Mol Genet Metab       Date:  2001-01       Impact factor: 4.797
View more
  64 in total

1.  Coding potential of laboratory and clinical strains of human cytomegalovirus.

Authors:  Eain Murphy; Dong Yu; Jane Grimwood; Jeremy Schmutz; Mark Dickson; Michael A Jarvis; Gabriele Hahn; Jay A Nelson; Richard M Myers; Thomas E Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

2.  Comprehensive mutational analysis of a herpesvirus gene in the viral genome context reveals a region essential for virus replication.

Authors:  Anja Bubeck; Markus Wagner; Zsolt Ruzsics; Mark Lötzerich; Margot Iglesias; Ila R Singh; Ulrich H Koszinowski
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

3.  RASCAL is a new human cytomegalovirus-encoded protein that localizes to the nuclear lamina and in cytoplasmic vesicles at late times postinfection.

Authors:  Matthew S Miller; Wendy E Furlong; Leesa Pennell; Marc Geadah; Laura Hertel
Journal:  J Virol       Date:  2010-04-14       Impact factor: 5.103

4.  Cellular and viral control over the initial events of human cytomegalovirus experimental latency in CD34+ cells.

Authors:  Ryan T Saffert; Rhiannon R Penkert; Robert F Kalejta
Journal:  J Virol       Date:  2010-03-24       Impact factor: 5.103

5.  Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores.

Authors:  Ronit Sharon-Friling; Joseph Goodhouse; Anamaris M Colberg-Poley; Thomas Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-29       Impact factor: 11.205

Review 6.  Human cytomegalovirus tropism for endothelial cells: not all endothelial cells are created equal.

Authors:  Michael A Jarvis; Jay A Nelson
Journal:  J Virol       Date:  2006-09-06       Impact factor: 5.103

7.  The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesis.

Authors:  Hiroki Isomura; Mark F Stinski; Ayumi Kudoh; Sanae Nakayama; Satoko Iwahori; Yoshitaka Sato; Tatsuya Tsurumi
Journal:  J Virol       Date:  2007-04-04       Impact factor: 5.103

8.  Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion.

Authors:  Brent J Ryckman; Michael A Jarvis; Derek D Drummond; Jay A Nelson; David C Johnson
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

9.  Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes.

Authors:  Gabriele Hahn; Maria Grazia Revello; Marco Patrone; Elena Percivalle; Giulia Campanini; Antonella Sarasini; Markus Wagner; Andrea Gallina; Gabriele Milanesi; Ulrich Koszinowski; Fausto Baldanti; Giuseppe Gerna
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

10.  The carboxy-terminal tail of human cytomegalovirus (HCMV) US28 regulates both chemokine-independent and chemokine-dependent signaling in HCMV-infected cells.

Authors:  Melissa P Stropes; Olivia D Schneider; William A Zagorski; Jeanette L C Miller; William E Miller
Journal:  J Virol       Date:  2009-07-15       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.