Literature DB >> 12176926

Minimal introns are not "junk".

Jun Yu1, Zhiyong Yang, Miho Kibukawa, Marcia Paddock, Douglas A Passey, Gane Ka-Shu Wong.   

Abstract

Intron-size distributions for most multicellular (and some unicellular) eukaryotes have a sharp peak at their "minimal intron" size. Across the human population, these minimal introns exhibit an abundance of insertion-deletion polymorphisms, the effect of which is to maintain their optimal size. We argue that minimal introns affect function by enhancing the rate at which mRNA is exported from the cell nucleus.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12176926      PMCID： PMC186636          DOI： 10.1101/gr.224602

Source DB:  PubMed          Journal:  Genome Res        ISSN： 1088-9051            Impact factor:   9.043


  34 in total

1.  Characterization of single-nucleotide polymorphisms in coding regions of human genes.

Authors:  M Cargill; D Altshuler; J Ireland; P Sklar; K Ardlie; N Patil; N Shaw; C R Lane; E P Lim; N Kalyanaraman; J Nemesh; L Ziaugra; L Friedland; A Rolfe; J Warrington; R Lipshutz; G Q Daley; E S Lander
Journal:  Nat Genet       Date:  1999-07       Impact factor: 38.330

Review 2.  Splicing regulation as a potential genetic modifier.

Authors:  Malka Nissim-Rafinia; Batsheva Kerem
Journal:  Trends Genet       Date:  2002-03       Impact factor: 11.639

3.  Intron presence-absence polymorphism in Drosophila driven by positive Darwinian selection.

Authors:  Ana Llopart; Josep M Comeron; Frédéric G Brunet; Daniel Lachaise; Manyuan Long
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

4.  A generic intron increases gene expression in transgenic mice.

Authors:  T Choi; M Huang; C Gorman; R Jaenisch
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

5.  Dissecting the regulatory circuitry of a eukaryotic genome.

Authors:  F C Holstege; E G Jennings; J J Wyrick; T I Lee; C J Hengartner; M R Green; T R Golub; E S Lander; R A Young
Journal:  Cell       Date:  1998-11-25       Impact factor: 41.582

6.  A DNA polymorphism discovery resource for research on human genetic variation.

Authors:  F S Collins; L D Brooks; A Chakravarti
Journal:  Genome Res       Date:  1998-12       Impact factor: 9.043

7.  Patterns and rates of indel evolution in processed pseudogenes from humans and murids.

Authors:  R Ophir; D Graur
Journal:  Gene       Date:  1997-12-31       Impact factor: 3.688

Review 8.  Exon recognition in vertebrate splicing.

Authors:  S M Berget
Journal:  J Biol Chem       Date:  1995-02-10       Impact factor: 5.157

9.  Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae.

Authors:  M Spingola; L Grate; D Haussler; M Ares
Journal:  RNA       Date:  1999-02       Impact factor: 4.942

10.  Heterologous introns can enhance expression of transgenes in mice.

Authors:  R D Palmiter; E P Sandgren; M R Avarbock; D D Allen; R L Brinster
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205
View more
  45 in total

1.  A population threshold for functional polymorphisms.

Authors:  Gane Ka-Shu Wong; Zhiyong Yang; Douglas A Passey; Miho Kibukawa; Marcia Paddock; Chun-Rong Liu; Lars Bolund; Jun Yu
Journal:  Genome Res       Date:  2003-08       Impact factor: 9.043

Review 2.  Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production.

Authors:  Keita Miyoshi; Tomohiro Miyoshi; Haruhiko Siomi
Journal:  Mol Genet Genomics       Date:  2010-07-02       Impact factor: 3.291

3.  Insertion/deletion and nucleotide polymorphism data reveal constraints in Drosophila melanogaster introns and intergenic regions.

Authors:  Lino Ometto; Wolfgang Stephan; David De Lorenzo
Journal:  Genetics       Date:  2005-01-16       Impact factor: 4.562

4.  Comparative genomic analysis links karyotypic evolution with genomic evolution in the Indian muntjac (Muntiacus muntjak vaginalis).

Authors:  Qi Zhou; Ling Huang; Jianguo Zhang; Xiangyi Zhao; Qingpeng Zhang; Fei Song; Jianxiang Chi; Fengtang Yang; Wen Wang
Journal:  Chromosoma       Date:  2006-06-22       Impact factor: 4.316

5.  Intronic deletions in the SLC34A3 gene: a cautionary tale for mutation analysis of hereditary hypophosphatemic rickets with hypercalciuria.

Authors:  Shoji Ichikawa; Shamir Tuchman; Leah R Padgett; Amie K Gray; H Jorge Baluarte; Michael J Econs
Journal:  Bone       Date:  2013-10-29       Impact factor: 4.398

6.  Systematic Computational Identification of Variants That Activate Exonic and Intronic Cryptic Splice Sites.

Authors:  Melissa Lee; Patrick Roos; Neeraj Sharma; Melis Atalar; Taylor A Evans; Matthew J Pellicore; Emily Davis; Anh-Thu N Lam; Susan E Stanley; Sara E Khalil; George M Solomon; Doug Walker; Karen S Raraigh; Briana Vecchio-Pagan; Mary Armanios; Garry R Cutting
Journal:  Am J Hum Genet       Date:  2017-05-04       Impact factor: 11.025

7.  A novel role for minimal introns: routing mRNAs to the cytosol.

Authors:  Jiang Zhu; Fuhong He; Dapeng Wang; Kan Liu; Dawei Huang; Jingfa Xiao; Jiayan Wu; Songnian Hu; Jun Yu
Journal:  PLoS One       Date:  2010-04-12       Impact factor: 3.240

8.  Both size and GC-content of minimal introns are selected in human populations.

Authors:  Dapeng Wang; Jun Yu
Journal:  PLoS One       Date:  2011-03-17       Impact factor: 3.240

9.  Selective and mutational patterns associated with gene expression in humans: influences on synonymous composition and intron presence.

Authors:  Josep M Comeron
Journal:  Genetics       Date:  2004-07       Impact factor: 4.562

10.  A method for identifying alternative or cryptic donor splice sites within gene and mRNA sequences. Comparisons among sequences from vertebrates, echinoderms and other groups.

Authors:  Katherine M Buckley; Liliana D Florea; L Courtney Smith
Journal:  BMC Genomics       Date:  2009-07-16       Impact factor: 3.969
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.