| Literature DB >> 12175613 |
Osmindo R Pires1, Antonio Sebben, Elisabeth F Schwartz, Simone W R Largura, Carlos Bloch, Rodrigo A V Morales, Carlos A Schwartz.
Abstract
Brachycephalus ephippium is a diurnal frog, that shows aposematic colouration and inhabits Atlantic forest leaf litter in south-eastern Brazil. The presence of tetrodotoxin (TTX) in the skin, liver and ovaries of B. ephippium was demonstrated. The skin (260 M.U./g) exhibited the highest toxicity followed by liver (177 M.U./g). TTX and its analogues, tetrodonic acid, 4-epitetrodotoxin and 4,9 anhydrotetrodotoxin were isolated and identified by HPLC followed by fluorimetric analysis. TTX and 11-nortetrodotoxin-6(S)-ol had their presence confirmed by mass spectrometry (MALDI-TOF). The results confirm Brachycephalidae as a fourth family of anurans containing TTX. Copright 2002 Elsevier Science Ltd.Entities:
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Year: 2002 PMID： 12175613 DOI： 10.1016/s0041-0101(01)00279-3
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033